SREBF2

sterol regulatory element binding transcription factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 Kidney Mouse YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
lipid metabolic process [GO:0006629],
cholesterol metabolic process [GO:0008203],
regulation of Notch signaling pathway [GO:0008593],
cellular response to starvation [GO:0009267],
positive regulation of cholesterol storage [GO:0010886],
SREBP signaling pathway [GO:0032933],
response to lipid [GO:0033993],
cholesterol homeostasis [GO:0042632],
regulation of cholesterol biosynthetic process [GO:0045540],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cellular response to low-density lipoprotein particle stimulus [GO:0071404],
cellular response to laminar fluid shear stress [GO:0071499],
negative regulation of cholesterol efflux [GO:0090370],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
regulation of mitophagy [GO:1903146],
positive regulation of protein targeting to mitochondrion [GO:1903955],
regulation of transcription, DNA-templated [GO:0006355],
steroid metabolic process [GO:0008202],
response to hormone [GO:0009725],
positive regulation of transcription, DNA-templated [GO:0045893],

Molecular Function:
C-8 sterol isomerase activity [GO:0000247],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
protein dimerization activity [GO:0046983],
E-box binding [GO:0070888],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
Golgi membrane [GO:0000139],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
ER to Golgi transport vesicle membrane [GO:0012507],
SREBP-SCAP-Insig complex [GO:0032937],
intracellular membrane-bounded organelle [GO:0043231],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
dendrite [GO:0030425],
cytoplasmic vesicle [GO:0031410],