SREBF1

sterol regulatory element binding transcription factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20615871 HeLa Human NO
24396695 HeLa Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31756344 Liver Mouse NO
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of heart rate by chemical signal [GO:0003062],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
lipid metabolic process [GO:0006629],
aging [GO:0007568],
circadian rhythm [GO:0007623],
cholesterol metabolic process [GO:0008203],
insulin receptor signaling pathway [GO:0008286],
lipid biosynthetic process [GO:0008610],
cellular response to starvation [GO:0009267],
response to glucose [GO:0009749],
positive regulation of triglyceride biosynthetic process [GO:0010867],
regulation of fatty acid metabolic process [GO:0019217],
lung development [GO:0030324],
intracellular receptor signaling pathway [GO:0030522],
positive regulation of histone deacetylation [GO:0031065],
regulation of protein stability [GO:0031647],
response to food [GO:0032094],
response to retinoic acid [GO:0032526],
response to progesterone [GO:0032570],
SREBP signaling pathway [GO:0032933],
response to glucagon [GO:0033762],
response to lipid [GO:0033993],
mRNA transcription from RNA polymerase II promoter [GO:0042789],
fat cell differentiation [GO:0045444],
regulation of cholesterol biosynthetic process [GO:0045540],
positive regulation of cholesterol biosynthetic process [GO:0045542],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of insulin secretion [GO:0046676],
response to cAMP [GO:0051591],
cellular response to fatty acid [GO:0071398],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
regulation of mitophagy [GO:1903146],
regulation of protein targeting to mitochondrion [GO:1903214],
regulation of transcription, DNA-templated [GO:0006355],
steroid metabolic process [GO:0008202],
positive regulation of fatty acid biosynthetic process [GO:0045723],
positive regulation of transcription, DNA-templated [GO:0045893],
regulation of insulin secretion [GO:0050796],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
sterol response element binding [GO:0032810],
macromolecular complex binding [GO:0044877],
protein dimerization activity [GO:0046983],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
Golgi membrane [GO:0000139],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
ER to Golgi transport vesicle membrane [GO:0012507],
integral component of membrane [GO:0016021],
macromolecular complex [GO:0032991],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
intracellular membrane-bounded organelle [GO:0043231],