SRC proto-oncogene, non-receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
14963003 HECs Human NO
16204065 HT18 Human NO
25736378 Primary cells derived from mammary gland Mammary gland Mouse NO
31806373 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
primary ovarian follicle growth [GO:0001545],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
cell cycle [GO:0007049],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
signal complex assembly [GO:0007172],
epidermal growth factor receptor signaling pathway [GO:0007173],
transforming growth factor beta receptor signaling pathway [GO:0007179],
G-protein coupled receptor signaling pathway [GO:0007186],
integrin-mediated signaling pathway [GO:0007229],
axon guidance [GO:0007411],
cell proliferation [GO:0008283],
response to mechanical stimulus [GO:0009612],
response to virus [GO:0009615],
response to acidic pH [GO:0010447],
regulation of epithelial cell migration [GO:0010632],
positive regulation of epithelial cell migration [GO:0010634],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of protein processing [GO:0010954],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
positive regulation of smooth muscle cell migration [GO:0014911],
viral process [GO:0016032],
macroautophagy [GO:0016236],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-tyrosine phosphorylation [GO:0018108],
regulation of cell-cell adhesion [GO:0022407],
cell differentiation [GO:0030154],
platelet activation [GO:0030168],
forebrain development [GO:0030900],
T cell costimulation [GO:0031295],
negative regulation of protein complex assembly [GO:0031333],
protein destabilization [GO:0031648],
response to nutrient levels [GO:0031667],
positive regulation of protein autophosphorylation [GO:0031954],
activation of protein kinase B activity [GO:0032148],
negative regulation of telomere maintenance via telomerase [GO:0032211],
cellular response to insulin stimulus [GO:0032869],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
positive regulation of integrin activation [GO:0033625],
adherens junction organization [GO:0034332],
substrate adhesion-dependent cell spreading [GO:0034446],
positive regulation of dephosphorylation [GO:0035306],
intracellular signal transduction [GO:0035556],
entry of bacterium into host cell [GO:0035635],
osteoclast development [GO:0036035],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ERBB2 signaling pathway [GO:0038128],
regulation of cell proliferation [GO:0042127],
odontogenesis [GO:0042476],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
regulation of vascular permeability [GO:0043114],
stress fiber assembly [GO:0043149],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of protein binding [GO:0043393],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
transcytosis [GO:0045056],
innate immune response [GO:0045087],
regulation of bone resorption [GO:0045124],
bone resorption [GO:0045453],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of insulin receptor signaling pathway [GO:0046628],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
neurotrophin TRK receptor signaling pathway [GO:0048011],
ephrin receptor signaling pathway [GO:0048013],
focal adhesion assembly [GO:0048041],
oogenesis [GO:0048477],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
progesterone receptor signaling pathway [GO:0050847],
leukocyte migration [GO:0050900],
positive regulation of small GTPase mediated signal transduction [GO:0051057],
response to mineralocorticoid [GO:0051385],
response to electrical stimulus [GO:0051602],
negative regulation of focal adhesion assembly [GO:0051895],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of mitochondrial depolarization [GO:0051902],
negative regulation of telomerase activity [GO:0051974],
uterus development [GO:0060065],
branching involved in mammary gland duct morphogenesis [GO:0060444],
regulation of cell projection assembly [GO:0060491],
cellular response to hydrogen peroxide [GO:0070301],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
response to interleukin-1 [GO:0070555],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to progesterone stimulus [GO:0071393],
cellular response to fatty acid [GO:0071398],
cellular response to hypoxia [GO:0071456],
cellular response to fluid shear stress [GO:0071498],
positive regulation of podosome assembly [GO:0071803],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
angiotensin-activated signaling pathway involved in heart process [GO:0086098],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
cell-cell adhesion [GO:0098609],
regulation of postsynaptic neurotransmitter receptor activity [GO:0098962],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997],
positive regulation of ovarian follicle development [GO:2000386],
positive regulation of lamellipodium morphogenesis [GO:2000394],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588],
regulation of early endosome to late endosome transport [GO:2000641],
negative regulation of anoikis [GO:2000811],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
regulation of caveolin-mediated endocytosis [GO:2001286],
immune system process [GO:0002376],
protein phosphorylation [GO:0006468],
positive regulation of gene expression [GO:0010628],
phosphorylation [GO:0016310],
cell migration [GO:0016477],
cellular response to reactive oxygen species [GO:0034614],
positive regulation of cell adhesion [GO:0045785],
positive regulation of protein transport [GO:0051222],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of intracellular signal transduction [GO:1902533],

Molecular Function:
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein kinase C binding [GO:0005080],
receptor binding [GO:0005102],
insulin receptor binding [GO:0005158],
integrin binding [GO:0005178],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
kinase activity [GO:0016301],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
heme binding [GO:0020037],
estrogen receptor binding [GO:0030331],
ubiquitin protein ligase binding [GO:0031625],
SH2 domain binding [GO:0042169],
ion channel binding [GO:0044325],
cadherin binding [GO:0045296],
ephrin receptor binding [GO:0046875],
ATPase binding [GO:0051117],
phosphoprotein binding [GO:0051219],
BMP receptor binding [GO:0070700],
growth factor receptor binding [GO:0070851],
connexin binding [GO:0071253],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
macromolecular complex binding [GO:0044877],
cell adhesion molecule binding [GO:0050839],

Cellular Component:
podosome [GO:0002102],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
lysosome [GO:0005764],
late endosome [GO:0005770],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
caveola [GO:0005901],
focal adhesion [GO:0005925],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
ruffle membrane [GO:0032587],
neuron projection [GO:0043005],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
nucleoplasm [GO:0005654],
cytoskeleton [GO:0005856],
membrane [GO:0016020],