SRC proto-oncogene, non-receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
14963003 HECs Human NO
16204065 HT18 Human NO
25736378 Primary cells derived from mammary gland Mammary gland Mouse NO
31806373 Primary fibroblasts derived from skin Human NO
32599680 HCT 116 Human No
32599680 SW480 Human No

GO terms:

Biological Process:
primary ovarian follicle growth [GO:0001545],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
cell cycle [GO:0007049],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
signal complex assembly [GO:0007172],
epidermal growth factor receptor signaling pathway [GO:0007173],
transforming growth factor beta receptor signaling pathway [GO:0007179],
G-protein coupled receptor signaling pathway [GO:0007186],
integrin-mediated signaling pathway [GO:0007229],
axon guidance [GO:0007411],
cell proliferation [GO:0008283],
response to mechanical stimulus [GO:0009612],
response to virus [GO:0009615],
response to acidic pH [GO:0010447],
regulation of epithelial cell migration [GO:0010632],
positive regulation of epithelial cell migration [GO:0010634],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of protein processing [GO:0010954],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
positive regulation of smooth muscle cell migration [GO:0014911],
viral process [GO:0016032],
macroautophagy [GO:0016236],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-tyrosine phosphorylation [GO:0018108],
regulation of cell-cell adhesion [GO:0022407],
cell differentiation [GO:0030154],
platelet activation [GO:0030168],
forebrain development [GO:0030900],
T cell costimulation [GO:0031295],
negative regulation of protein complex assembly [GO:0031333],
protein destabilization [GO:0031648],
response to nutrient levels [GO:0031667],
positive regulation of protein autophosphorylation [GO:0031954],
activation of protein kinase B activity [GO:0032148],
negative regulation of telomere maintenance via telomerase [GO:0032211],
cellular response to insulin stimulus [GO:0032869],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
positive regulation of integrin activation [GO:0033625],
adherens junction organization [GO:0034332],
substrate adhesion-dependent cell spreading [GO:0034446],
positive regulation of dephosphorylation [GO:0035306],
intracellular signal transduction [GO:0035556],
entry of bacterium into host cell [GO:0035635],
osteoclast development [GO:0036035],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ERBB2 signaling pathway [GO:0038128],
regulation of cell proliferation [GO:0042127],
odontogenesis [GO:0042476],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
regulation of vascular permeability [GO:0043114],
stress fiber assembly [GO:0043149],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of protein binding [GO:0043393],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
transcytosis [GO:0045056],
innate immune response [GO:0045087],
regulation of bone resorption [GO:0045124],
bone resorption [GO:0045453],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of insulin receptor signaling pathway [GO:0046628],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
neurotrophin TRK receptor signaling pathway [GO:0048011],
ephrin receptor signaling pathway [GO:0048013],
focal adhesion assembly [GO:0048041],
oogenesis [GO:0048477],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
progesterone receptor signaling pathway [GO:0050847],
leukocyte migration [GO:0050900],
positive regulation of small GTPase mediated signal transduction [GO:0051057],
response to mineralocorticoid [GO:0051385],
response to electrical stimulus [GO:0051602],
negative regulation of focal adhesion assembly [GO:0051895],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of mitochondrial depolarization [GO:0051902],
negative regulation of telomerase activity [GO:0051974],
uterus development [GO:0060065],
branching involved in mammary gland duct morphogenesis [GO:0060444],
regulation of cell projection assembly [GO:0060491],
cellular response to hydrogen peroxide [GO:0070301],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
response to interleukin-1 [GO:0070555],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to progesterone stimulus [GO:0071393],
cellular response to fatty acid [GO:0071398],
cellular response to hypoxia [GO:0071456],
cellular response to fluid shear stress [GO:0071498],
positive regulation of podosome assembly [GO:0071803],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
angiotensin-activated signaling pathway involved in heart process [GO:0086098],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
cell-cell adhesion [GO:0098609],
regulation of postsynaptic neurotransmitter receptor activity [GO:0098962],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997],
positive regulation of ovarian follicle development [GO:2000386],
positive regulation of lamellipodium morphogenesis [GO:2000394],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588],
regulation of early endosome to late endosome transport [GO:2000641],
negative regulation of anoikis [GO:2000811],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
regulation of caveolin-mediated endocytosis [GO:2001286],
immune system process [GO:0002376],
protein phosphorylation [GO:0006468],
positive regulation of gene expression [GO:0010628],
phosphorylation [GO:0016310],
cell migration [GO:0016477],
cellular response to reactive oxygen species [GO:0034614],
positive regulation of cell adhesion [GO:0045785],
positive regulation of protein transport [GO:0051222],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of intracellular signal transduction [GO:1902533],

Molecular Function:
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein kinase C binding [GO:0005080],
receptor binding [GO:0005102],
insulin receptor binding [GO:0005158],
integrin binding [GO:0005178],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
kinase activity [GO:0016301],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
heme binding [GO:0020037],
estrogen receptor binding [GO:0030331],
ubiquitin protein ligase binding [GO:0031625],
SH2 domain binding [GO:0042169],
ion channel binding [GO:0044325],
cadherin binding [GO:0045296],
ephrin receptor binding [GO:0046875],
ATPase binding [GO:0051117],
phosphoprotein binding [GO:0051219],
BMP receptor binding [GO:0070700],
growth factor receptor binding [GO:0070851],
connexin binding [GO:0071253],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
macromolecular complex binding [GO:0044877],
cell adhesion molecule binding [GO:0050839],

Cellular Component:
podosome [GO:0002102],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
lysosome [GO:0005764],
late endosome [GO:0005770],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
caveola [GO:0005901],
focal adhesion [GO:0005925],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
ruffle membrane [GO:0032587],
neuron projection [GO:0043005],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
nucleoplasm [GO:0005654],
cytoskeleton [GO:0005856],
membrane [GO:0016020],