SQSTM1

sequestosome 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
22098537 BEC Liver Human NO
30693443 Cochlea Mouse NO
30892080 Primary epithelial cells derived from lung Mouse NO
31469660 Primary neurons derived from brain Rat NO
31481873 HT22 Mouse NO
31559522 Primary cells derived from periodontium Human NO
31762159 Primary neurons derived from brain Rat NO
31920551 HEI-OC1 Mouse NO
31945125 Primary astrocytes derived from brain Human YES
32047439 Primary endothelial progenitor cells isolated from bone marrow Rat NO
32963699 Primary endothelial cells derived from aorta Human No
32963699 Primary endothelial cells derived from aorta Human No
32466233 TIG-3 Human NO
33299530 kidney Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31491600 HAEC Human NO
31931659 WI-38 Human NO
32100342 MCF 10A Human NO
32846959 MCF7, MDA-MB-231 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
mitophagy [GO:0000422],
macromitophagy [GO:0000423],
positive regulation of protein phosphorylation [GO:0001934],
immune system process [GO:0002376],
response to ischemia [GO:0002931],
protein phosphorylation [GO:0006468],
ubiquitin-dependent protein catabolic process [GO:0006511],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
mitochondrion organization [GO:0007005],
endosome organization [GO:0007032],
protein localization [GO:0008104],
regulation of mitochondrion organization [GO:0010821],
endosomal transport [GO:0016197],
macroautophagy [GO:0016236],
cell differentiation [GO:0030154],
negative regulation of protein ubiquitination [GO:0031397],
intracellular signal transduction [GO:0035556],
aggrephagy [GO:0035973],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of Ras protein signal transduction [GO:0046578],
regulation of protein complex stability [GO:0061635],
interleukin-1-mediated signaling pathway [GO:0070498],
response to mitochondrial depolarisation [GO:0098780],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of protein localization to plasma membrane [GO:1903078],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
receptor tyrosine kinase binding [GO:0030971],
ubiquitin protein ligase binding [GO:0031625],
ionotropic glutamate receptor binding [GO:0035255],
SH2 domain binding [GO:0042169],
identical protein binding [GO:0042802],
ubiquitin binding [GO:0043130],
macromolecular complex binding [GO:0044877],
K63-linked polyubiquitin binding [GO:0070530],
transcription cofactor activity [GO:0003712],
metal ion binding [GO:0046872],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
cytoplasmic mRNA processing body [GO:0000932],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
late endosome [GO:0005770],
autophagosome [GO:0005776],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
inclusion body [GO:0016234],
aggresome [GO:0016235],
PML body [GO:0016605],
sarcomere [GO:0030017],
intracellular membrane-bounded organelle [GO:0043231],
amphisome [GO:0044753],
autolysosome [GO:0044754],
extracellular exosome [GO:0070062],
sperm midpiece [GO:0097225],
Lewy body [GO:0097413],
nucleus [GO:0005634],
lysosome [GO:0005764],
endosome [GO:0005768],
cytoplasmic vesicle [GO:0031410],