SQLE

squalene epoxidase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31983656 MSC Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 Kidney Mouse YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cholesterol biosynthetic process [GO:0006695],
cellular aromatic compound metabolic process [GO:0006725],
cholesterol metabolic process [GO:0008203],
response to organic substance [GO:0010033],
sterol biosynthetic process [GO:0016126],
regulation of cell proliferation [GO:0042127],
regulation of cholesterol biosynthetic process [GO:0045540],
oxidation-reduction process [GO:0055114],

Molecular Function:
squalene monooxygenase activity [GO:0004506],
protein binding [GO:0005515],
FAD binding [GO:0071949],
oxidoreductase activity [GO:0016491],
flavin adenine dinucleotide binding [GO:0050660],

Cellular Component:
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
integral component of membrane [GO:0016021],
intracellular membrane-bounded organelle [GO:0043231],
membrane [GO:0016020],