SPRY2

sprouty RTK signaling antagonist 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES
32972203 heartDPI7 vs healthy nan Mouse NO

GO terms:

Biological Process:
establishment of mitotic spindle orientation [GO:0000132],
sensory perception of sound [GO:0007605],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
negative regulation of peptidyl-threonine phosphorylation [GO:0010801],
negative regulation of angiogenesis [GO:0016525],
positive regulation of cell migration [GO:0030335],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
negative regulation of cell projection organization [GO:0031345],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of GTPase activity [GO:0034260],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
inner ear morphogenesis [GO:0042472],
negative regulation of apoptotic process [GO:0043066],
negative regulation of MAP kinase activity [GO:0043407],
cell fate commitment [GO:0045165],
negative regulation of Ras protein signal transduction [GO:0046580],
animal organ development [GO:0048513],
negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387],
positive regulation of protein kinase B signaling [GO:0051897],
lung growth [GO:0060437],
bud elongation involved in lung branching [GO:0060449],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747],
negative regulation of lens fiber cell differentiation [GO:1902747],
cellular response to leukemia inhibitory factor [GO:1990830],
multicellular organism development [GO:0007275],
regulation of signal transduction [GO:0009966],
lung development [GO:0030324],
regulation of cell proliferation [GO:0042127],
regulation of cell differentiation [GO:0045595],
branching morphogenesis of an epithelial tube [GO:0048754],
lung morphogenesis [GO:0060425],
respiratory system development [GO:0060541],

Molecular Function:
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
protein serine/threonine kinase inhibitor activity [GO:0030291],
protein serine/threonine kinase activator activity [GO:0043539],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
actin cytoskeleton [GO:0015629],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
ruffle membrane [GO:0032587],
microtubule end [GO:1990752],
cytoplasm [GO:0005737],
microtubule [GO:0005874],
cell projection [GO:0042995],