SPG7 matrix AAA peptidase subunit, paraplegin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
mitochondrial calcium ion transport [GO:0006851],
mitochondrion organization [GO:0007005],
nervous system development [GO:0007399],
mitochondrial fusion [GO:0008053],
anterograde axonal transport [GO:0008089],
mitochondrial protein processing [GO:0034982],
cristae formation [GO:0042407],
regulation of mitochondrial membrane permeability [GO:0046902],
macromolecular complex assembly [GO:0065003],
mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686],
cell adhesion [GO:0007155],
regulation of cell adhesion [GO:0030155],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
ATP binding [GO:0005524],
peptidase activity [GO:0008233],
zinc ion binding [GO:0008270],
unfolded protein binding [GO:0051082],
nucleotide binding [GO:0000166],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
m-AAA complex [GO:0005745],
mitochondrial permeability transition pore complex [GO:0005757],
axon cytoplasm [GO:1904115],
membrane [GO:0016020],
integral component of membrane [GO:0016021],