SPARC

secreted protein acidic and cysteine rich

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
31760435 HuT 102, Jurkat Human NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO
31915373 Hheart_LA_VS healthy nan Human NO

GO terms:

Biological Process:
ossification [GO:0001503],
negative regulation of endothelial cell proliferation [GO:0001937],
platelet degranulation [GO:0002576],
receptor-mediated endocytosis [GO:0006898],
heart development [GO:0007507],
response to gravity [GO:0009629],
response to lead ion [GO:0010288],
positive regulation of endothelial cell migration [GO:0010595],
negative regulation of angiogenesis [GO:0016525],
regulation of cell morphogenesis [GO:0022604],
extracellular matrix organization [GO:0030198],
lung development [GO:0030324],
response to lipopolysaccharide [GO:0032496],
response to L-ascorbic acid [GO:0033591],
response to cytokine [GO:0034097],
wound healing [GO:0042060],
response to peptide hormone [GO:0043434],
pigmentation [GO:0043473],
response to ethanol [GO:0045471],
response to cadmium ion [GO:0046686],
inner ear development [GO:0048839],
anatomical structure development [GO:0048856],
regulation of synapse organization [GO:0050807],
response to glucocorticoid [GO:0051384],
response to cAMP [GO:0051591],
response to calcium ion [GO:0051592],
bone development [GO:0060348],
cellular response to growth factor stimulus [GO:0071363],
regulation of cell proliferation [GO:0042127],

Molecular Function:
extracellular matrix structural constituent [GO:0005201],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
collagen binding [GO:0005518],
extracellular matrix binding [GO:0050840],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
nuclear matrix [GO:0016363],
platelet alpha granule [GO:0031091],
platelet alpha granule membrane [GO:0031092],
platelet alpha granule lumen [GO:0031093],
intracellular membrane-bounded organelle [GO:0043231],
endocytic vesicle lumen [GO:0071682],
glutamatergic synapse [GO:0098978],
nucleus [GO:0005634],
extracellular matrix [GO:0031012],
vesicle [GO:0031982],
synapse [GO:0045202],