SOX11

SRY-box transcription factor 11

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
skeletal system development [GO:0001501],
kidney development [GO:0001822],
neural tube formation [GO:0001841],
lens morphogenesis in camera-type eye [GO:0002089],
outflow tract morphogenesis [GO:0003151],
cardiac ventricle formation [GO:0003211],
noradrenergic neuron differentiation [GO:0003357],
regulation of transcription, DNA-templated [GO:0006355],
positive regulation of cell proliferation [GO:0008284],
anatomical structure morphogenesis [GO:0009653],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
oligodendrocyte development [GO:0014003],
glial cell proliferation [GO:0014009],
neural crest cell development [GO:0014032],
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015],
spinal cord development [GO:0021510],
glial cell development [GO:0021782],
cell differentiation [GO:0030154],
neuron differentiation [GO:0030182],
positive regulation of BMP signaling pathway [GO:0030513],
positive regulation of hippo signaling [GO:0035332],
skeletal muscle cell differentiation [GO:0035914],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of ossification [GO:0045778],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of hormone secretion [GO:0046887],
sympathetic nervous system development [GO:0048485],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic skeletal system morphogenesis [GO:0048704],
negative regulation of lymphocyte proliferation [GO:0050672],
positive regulation of neurogenesis [GO:0050769],
hard palate development [GO:0060022],
soft palate development [GO:0060023],
limb bud formation [GO:0060174],
negative regulation of glial cell proliferation [GO:0060253],
ventricular septum morphogenesis [GO:0060412],
lung morphogenesis [GO:0060425],
negative regulation of cell death [GO:0060548],
neuroepithelial cell differentiation [GO:0060563],
eyelid development in camera-type eye [GO:0061029],
somite development [GO:0061053],
cornea development in camera-type eye [GO:0061303],
closure of optic fissure [GO:0061386],
signal transduction involved in cell cycle checkpoint [GO:0072395],
positive regulation of stem cell proliferation [GO:2000648],
negative regulation of transcription regulatory region DNA binding [GO:2000678],
positive regulation of lens epithelial cell proliferation [GO:2001111],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription coactivator activity [GO:0003713],
DNA binding [GO:0003677],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],