SORT1

sortilin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
ossification [GO:0001503],
protein targeting to lysosome [GO:0006622],
post-Golgi vesicle-mediated transport [GO:0006892],
Golgi to endosome transport [GO:0006895],
endocytosis [GO:0006897],
G-protein coupled receptor signaling pathway [GO:0007186],
neuropeptide signaling pathway [GO:0007218],
multicellular organism development [GO:0007275],
endosome to lysosome transport [GO:0008333],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
regulation of gene expression [GO:0010468],
myotube differentiation [GO:0014902],
vesicle organization [GO:0016050],
endosome transport via multivesicular body sorting pathway [GO:0032509],
response to insulin [GO:0032868],
nerve growth factor signaling pathway [GO:0038180],
negative regulation of fat cell differentiation [GO:0045599],
glucose import [GO:0046323],
neurotrophin TRK receptor signaling pathway [GO:0048011],
plasma membrane to endosome transport [GO:0048227],
negative regulation of lipoprotein lipase activity [GO:0051005],
positive regulation of epithelial cell apoptotic process [GO:1904037],
cell differentiation [GO:0030154],

Molecular Function:
protein binding [GO:0005515],
nerve growth factor receptor activity [GO:0010465],
enzyme binding [GO:0019899],
neurotensin receptor activity, non-G-protein coupled [GO:0030379],
nerve growth factor binding [GO:0048406],
retromer complex binding [GO:1905394],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
early endosome [GO:0005769],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
clathrin-coated vesicle [GO:0030136],
trans-Golgi network transport vesicle [GO:0030140],
dendrite [GO:0030425],
cytoplasmic vesicle membrane [GO:0030659],
cytoplasmic vesicle [GO:0031410],
nuclear membrane [GO:0031965],
Golgi cisterna membrane [GO:0032580],
neuronal cell body [GO:0043025],
perinuclear region of cytoplasm [GO:0048471],
nucleus [GO:0005634],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],
intracellular membrane-bounded organelle [GO:0043231],