SORL1

sortilin related receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
diet induced thermogenesis [GO:0002024],
protein targeting [GO:0006605],
protein targeting to lysosome [GO:0006622],
post-Golgi vesicle-mediated transport [GO:0006892],
receptor-mediated endocytosis [GO:0006898],
neuropeptide signaling pathway [GO:0007218],
negative regulation of triglyceride catabolic process [GO:0010897],
regulation of smooth muscle cell migration [GO:0014910],
negative regulation of BMP signaling pathway [GO:0030514],
negative regulation of protein complex assembly [GO:0031333],
negative regulation of protein binding [GO:0032091],
protein localization to Golgi apparatus [GO:0034067],
insulin receptor recycling [GO:0038020],
negative regulation of MAP kinase activity [GO:0043407],
cellular protein metabolic process [GO:0044267],
protein retention in Golgi apparatus [GO:0045053],
positive regulation of protein catabolic process [GO:0045732],
positive regulation of insulin receptor signaling pathway [GO:0046628],
negative regulation of neurogenesis [GO:0050768],
protein maturation [GO:0051604],
positive regulation of protein exit from endoplasmic reticulum [GO:0070863],
positive regulation of glial cell-derived neurotrophic factor secretion [GO:1900168],
negative regulation of neuron death [GO:1901215],
negative regulation of beta-amyloid formation [GO:1902430],
positive regulation of choline O-acetyltransferase activity [GO:1902771],
negative regulation of tau-protein kinase activity [GO:1902948],
positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953],
positive regulation of early endosome to recycling endosome transport [GO:1902955],
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960],
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963],
positive regulation of protein localization to early endosome [GO:1902966],
negative regulation of neurofibrillary tangle assembly [GO:1902997],
positive regulation of adipose tissue development [GO:1904179],
adaptive thermogenesis [GO:1990845],
positive regulation of endocytic recycling [GO:2001137],
endocytosis [GO:0006897],
multicellular organism development [GO:0007275],
cell migration [GO:0016477],

Molecular Function:
beta-amyloid binding [GO:0001540],
transmembrane signaling receptor activity [GO:0004888],
low-density lipoprotein receptor activity [GO:0005041],
protein binding [GO:0005515],
low-density lipoprotein particle binding [GO:0030169],
ADP-ribosylation factor binding [GO:0030306],
neuropeptide binding [GO:0042923],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular space [GO:0005615],
nuclear envelope lumen [GO:0005641],
endosome [GO:0005768],
early endosome [GO:0005769],
multivesicular body [GO:0005771],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
transport vesicle membrane [GO:0030658],
early endosome membrane [GO:0031901],
Golgi cisterna [GO:0031985],
multivesicular body membrane [GO:0032585],
recycling endosome [GO:0055037],
recycling endosome membrane [GO:0055038],
extracellular exosome [GO:0070062],
perinucleolar compartment [GO:0097356],
extracellular region [GO:0005576],
cytoplasmic vesicle [GO:0031410],
neuronal cell body [GO:0043025],
perinuclear region of cytoplasm [GO:0048471],