small nuclear ribonucleoprotein U1 subunit 70

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
mRNA splicing, via spliceosome [GO:0000398],
regulation of ATPase activity [GO:0043462],
regulation of RNA splicing [GO:0043484],
positive regulation of mRNA splicing, via spliceosome [GO:0048026],
negative regulation of protein refolding [GO:0061084],
negative regulation of chaperone-mediated autophagy [GO:1904715],

Molecular Function:
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
protein binding [GO:0005515],
snRNA binding [GO:0017069],
U1 snRNA binding [GO:0030619],
nucleic acid binding [GO:0003676],
U1 snRNP binding [GO:1990446],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
spliceosomal complex [GO:0005681],
U1 snRNP [GO:0005685],
nuclear speck [GO:0016607],
U2-type prespliceosome [GO:0071004],
cytoplasm [GO:0005737],