BIRC5

baculoviral IAP repeat containing 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29872320 KYSE-15 , KYSE-41 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20503268 NCI-H1299 Human NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
27531889 HEK 293T, HeLa Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES
29658609 NCI-H358, NCI-H441 Human NO
30626320 HBEC Human NO
30977188 MSC Human YES
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
chromosome segregation [GO:0007059],
sensory perception of sound [GO:0007605],
positive regulation of cell proliferation [GO:0008284],
cytokine-mediated signaling pathway [GO:0019221],
protein complex localization [GO:0031503],
regulation of apoptotic process [GO:0042981],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
negative regulation of transcription, DNA-templated [GO:0045892],
cell division [GO:0051301],
mitotic spindle assembly [GO:0090307],
G2/M transition of mitotic cell cycle [GO:0000086],
microtubule cytoskeleton organization [GO:0000226],
mitotic cytokinesis [GO:0000281],
cell cycle [GO:0007049],
mitotic spindle assembly checkpoint [GO:0007094],
regulation of mitotic cell cycle [GO:0007346],
embryo development [GO:0009790],
negative regulation of peptidase activity [GO:0010466],
positive regulation of exit from mitosis [GO:0031536],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of cell cycle [GO:0045787],
positive regulation of mitotic cell cycle [GO:0045931],
establishment of chromosome localization [GO:0051303],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
regulation of type B pancreatic cell proliferation [GO:0061469],

Molecular Function:
protein binding [GO:0005515],
microtubule binding [GO:0008017],
Ran GTPase binding [GO:0008536],
enzyme binding [GO:0019899],
identical protein binding [GO:0042802],
cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027],
metal ion binding [GO:0046872],
chaperone binding [GO:0051087],
cysteine-type endopeptidase inhibitor activity [GO:0004869],
zinc ion binding [GO:0008270],
tubulin binding [GO:0015631],
peptidase inhibitor activity [GO:0030414],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],

Cellular Component:
nuclear chromosome [GO:0000228],
chromosome, centromeric region [GO:0000775],
condensed chromosome kinetochore [GO:0000777],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
spindle microtubule [GO:0005876],
midbody [GO:0030496],
chromosome passenger complex [GO:0032133],
kinetochore [GO:0000776],
chromosome [GO:0005694],
centriole [GO:0005814],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
cytoplasmic microtubule [GO:0005881],
apical plasma membrane [GO:0016324],
interphase microtubule organizing center [GO:0031021],