SNF8 subunit of ESCRT-II

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
regulation of transcription from RNA polymerase II promoter [GO:0006357],
positive regulation of gene expression [GO:0010628],
regulation of multivesicular body size involved in endosome transport [GO:0010797],
endosomal transport [GO:0016197],
macroautophagy [GO:0016236],
endocytic recycling [GO:0032456],
multivesicular body assembly [GO:0036258],
regulation of protein catabolic process [GO:0042176],
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328],
regulation of MAP kinase activity [GO:0043405],
early endosome to late endosome transport [GO:0045022],
positive regulation of protein catabolic process [GO:0045732],
regulation of protein complex stability [GO:0061635],
multivesicular body sorting pathway [GO:0071985],
positive regulation of exosomal secretion [GO:1903543],
regulation of viral budding via host ESCRT complex [GO:1903772],
protein transport [GO:0015031],

Molecular Function:
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
transcription factor binding [GO:0008134],
channel regulator activity [GO:0016247],
protein homodimerization activity [GO:0042803],
protein N-terminus binding [GO:0047485],

Cellular Component:
ESCRT II complex [GO:0000814],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
membrane [GO:0016020],
late endosome membrane [GO:0031902],
perinuclear region of cytoplasm [GO:0048471],
recycling endosome [GO:0055037],
extracellular exosome [GO:0070062],
endosome [GO:0005768],