ACLY

ATP citrate lyase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20615871 HeLa Human NO
31945054 IMR-90 Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25367309 HDFs, HEK 293T, HCT116 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
acetyl-CoA biosynthetic process [GO:0006085],
citrate metabolic process [GO:0006101],
oxaloacetate metabolic process [GO:0006107],
fatty acid biosynthetic process [GO:0006633],
cholesterol biosynthetic process [GO:0006695],
lipid biosynthetic process [GO:0008610],
coenzyme A metabolic process [GO:0015936],
positive regulation of cellular metabolic process [GO:0031325],
neutrophil degranulation [GO:0043312],
fatty-acyl-CoA biosynthetic process [GO:0046949],
acetyl-CoA metabolic process [GO:0006084],
lipid metabolic process [GO:0006629],

Molecular Function:
ATP citrate synthase activity [GO:0003878],
protein binding [GO:0005515],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
transferase activity [GO:0016740],
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [GO:0046912],

Cellular Component:
extracellular region [GO:0005576],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
azurophil granule lumen [GO:0035578],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],