SMUG1

single-strand-selective monofunctional uracil-DNA glycosylase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
base-excision repair [GO:0006284],
depyrimidination [GO:0045008],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703],
DNA binding [GO:0003677],
uracil DNA N-glycosylase activity [GO:0004844],
protein binding [GO:0005515],
single-strand selective uracil DNA N-glycosylase activity [GO:0017065],
DNA N-glycosylase activity [GO:0019104],
oxidized base lesion DNA N-glycosylase activity [GO:0000702],
single-stranded DNA binding [GO:0003697],
hydrolase activity [GO:0016787],

Cellular Component:
fibrillar center [GO:0001650],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytosol [GO:0005829],
nucleus [GO:0005634],