SMO

smoothened, frizzled class receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
vasculogenesis [GO:0001570],
osteoblast differentiation [GO:0001649],
in utero embryonic development [GO:0001701],
cell fate specification [GO:0001708],
neural crest cell migration [GO:0001755],
heart looping [GO:0001947],
positive regulation of neuroblast proliferation [GO:0002052],
positive regulation of mesenchymal cell proliferation [GO:0002053],
determination of left/right asymmetry in lateral mesoderm [GO:0003140],
type B pancreatic cell development [GO:0003323],
G-protein coupled receptor signaling pathway [GO:0007186],
smoothened signaling pathway [GO:0007224],
positive regulation of hh target transcription factor activity [GO:0007228],
ventral midline determination [GO:0007371],
central nervous system development [GO:0007417],
midgut development [GO:0007494],
anterior/posterior pattern specification [GO:0009952],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
dentate gyrus development [GO:0021542],
cerebellar cortex morphogenesis [GO:0021696],
thalamus development [GO:0021794],
dorsal/ventral neural tube patterning [GO:0021904],
smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021910],
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938],
central nervous system neuron differentiation [GO:0021953],
cerebral cortex development [GO:0021987],
positive regulation of cell migration [GO:0030335],
negative regulation of epithelial cell differentiation [GO:0030857],
hair follicle morphogenesis [GO:0031069],
protein localization to nucleus [GO:0034504],
multicellular organism growth [GO:0035264],
positive regulation of multicellular organism growth [GO:0040018],
positive regulation of protein import into nucleus [GO:0042307],
odontogenesis of dentin-containing tooth [GO:0042475],
negative regulation of apoptotic process [GO:0043066],
negative regulation of DNA binding [GO:0043392],
positive regulation of smoothened signaling pathway [GO:0045880],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of organ growth [GO:0046622],
astrocyte activation [GO:0048143],
skeletal muscle fiber development [GO:0048741],
smooth muscle tissue development [GO:0048745],
forebrain morphogenesis [GO:0048853],
homeostasis of number of cells within a tissue [GO:0048873],
positive regulation of epithelial cell proliferation [GO:0050679],
protein stabilization [GO:0050821],
myoblast migration [GO:0051451],
negative regulation of hair follicle development [GO:0051799],
contact inhibition [GO:0060242],
atrial septum morphogenesis [GO:0060413],
mammary gland epithelial cell differentiation [GO:0060644],
epithelial-mesenchymal cell signaling [GO:0060684],
somite development [GO:0061053],
pancreas morphogenesis [GO:0061113],
left/right axis specification [GO:0070986],
cellular response to cholesterol [GO:0071397],
commissural neuron axon guidance [GO:0071679],
mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
regulation of stem cell population maintenance [GO:2000036],
regulation of heart morphogenesis [GO:2000826],
ossification [GO:0001503],
heart morphogenesis [GO:0003007],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],
determination of left/right symmetry [GO:0007368],
pattern specification process [GO:0007389],
positive regulation of cell proliferation [GO:0008284],
dorsal/ventral pattern formation [GO:0009953],
regulation of gene expression [GO:0010468],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
cell development [GO:0048468],
digestive tract development [GO:0048565],
embryonic organ development [GO:0048568],
developmental growth [GO:0048589],
axon extension involved in axon guidance [GO:0048846],
negative regulation of neuron death [GO:1901215],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
positive regulation of neural precursor cell proliferation [GO:2000179],

Molecular Function:
G-protein coupled receptor activity [GO:0004930],
patched binding [GO:0005113],
protein binding [GO:0005515],
drug binding [GO:0008144],
transmembrane signaling receptor activity [GO:0004888],

Cellular Component:
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
caveola [GO:0005901],
cilium [GO:0005929],
integral component of membrane [GO:0016021],
dendrite [GO:0030425],
endocytic vesicle membrane [GO:0030666],
intracellular membrane-bounded organelle [GO:0043231],
ciliary membrane [GO:0060170],
extracellular exosome [GO:0070062],
ciliary tip [GO:0097542],
9+0 non-motile cilium [GO:0097731],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
dendritic growth cone [GO:0044294],
axonal growth cone [GO:0044295],