SMC6

structural maintenance of chromosomes 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17589526 SUSM-1, U2OS, Saos-2, SW-26 Human NO
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
telomere maintenance via recombination [GO:0000722],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
positive regulation of chromosome segregation [GO:0051984],
cellular senescence [GO:0090398],

Molecular Function:
nucleotide binding [GO:0000166],
ATP binding [GO:0005524],
ubiquitin protein ligase binding [GO:0031625],
protein binding [GO:0005515],

Cellular Component:
chromosome, centromeric region [GO:0000775],
chromosome, telomeric region [GO:0000781],
sex chromosome [GO:0000803],
intracellular [GO:0005622],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
PML body [GO:0016605],
Smc5-Smc6 complex [GO:0030915],
interchromatin granule [GO:0035061],
site of double-strand break [GO:0035861],
mitotic spindle pole [GO:0097431],
nuclear speck [GO:0016607],