SMC5

structural maintenance of chromosomes 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17589526 SUSM-1, U2OS, Saos-2, SW-26 Human NO
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
telomere maintenance via recombination [GO:0000722],
double-strand break repair via homologous recombination [GO:0000724],
double-strand break repair via nonhomologous end joining [GO:0006303],
cellular response to DNA damage stimulus [GO:0006974],
sister chromatid cohesion [GO:0007062],
positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184],
cell division [GO:0051301],
positive regulation of chromosome segregation [GO:0051984],
cellular senescence [GO:0090398],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
cell cycle [GO:0007049],
chromosome segregation [GO:0007059],
internal peptidyl-lysine acetylation [GO:0018393],
stem cell population maintenance [GO:0019827],
chromosome condensation [GO:0030261],
mitotic cell cycle phase transition [GO:0044772],
protein localization to chromosome, centromeric region [GO:0071459],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
nucleotide binding [GO:0000166],
molecular_function [GO:0003674],

Cellular Component:
chromosome, telomeric region [GO:0000781],
sex chromosome [GO:0000803],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
PML body [GO:0016605],
nuclear speck [GO:0016607],
cell junction [GO:0030054],
Smc5-Smc6 complex [GO:0030915],
interchromatin granule [GO:0035061],
site of double-strand break [GO:0035861],
chromosome, centromeric region [GO:0000775],
chromosome [GO:0005694],
cytoplasm [GO:0005737],