SMC3

structural maintenance of chromosomes 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
mitotic cell cycle [GO:0000278],
regulation of DNA replication [GO:0006275],
DNA repair [GO:0006281],
sister chromatid cohesion [GO:0007062],
stem cell population maintenance [GO:0019827],
cell division [GO:0051301],
meiotic cell cycle [GO:0051321],
mitotic spindle assembly [GO:0090307],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
chromosome organization [GO:0051276],

Molecular Function:
chromatin binding [GO:0003682],
microtubule motor activity [GO:0003777],
protein binding [GO:0005515],
ATP binding [GO:0005524],
mediator complex binding [GO:0036033],
protein heterodimerization activity [GO:0046982],
beta-tubulin binding [GO:0048487],
dynein complex binding [GO:0070840],
nucleotide binding [GO:0000166],

Cellular Component:
chromosome, centromeric region [GO:0000775],
chromatin [GO:0000785],
lateral element [GO:0000800],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
cytosol [GO:0005829],
cohesin complex [GO:0008278],
nuclear matrix [GO:0016363],
meiotic cohesin complex [GO:0030893],
nuclear meiotic cohesin complex [GO:0034991],
mitotic spindle pole [GO:0097431],
basement membrane [GO:0005604],
nucleus [GO:0005634],