SMC1A

structural maintenance of chromosomes 1A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27731420 IMR-90 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitotic sister chromatid segregation [GO:0000070],
DNA repair [GO:0006281],
sister chromatid cohesion [GO:0007062],
mitotic sister chromatid cohesion [GO:0007064],
response to radiation [GO:0009314],
stem cell population maintenance [GO:0019827],
cell division [GO:0051301],
meiotic cell cycle [GO:0051321],
response to DNA damage checkpoint signaling [GO:0072423],
mitotic spindle assembly [GO:0090307],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
chromosome organization [GO:0051276],

Molecular Function:
chromatin binding [GO:0003682],
RNA binding [GO:0003723],
protein binding [GO:0005515],
ATP binding [GO:0005524],
mediator complex binding [GO:0036033],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],

Cellular Component:
chromosome, centromeric region [GO:0000775],
kinetochore [GO:0000776],
condensed chromosome kinetochore [GO:0000777],
condensed nuclear chromosome [GO:0000794],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
cytosol [GO:0005829],
cohesin complex [GO:0008278],
nuclear matrix [GO:0016363],
meiotic cohesin complex [GO:0030893],
mitotic spindle pole [GO:0097431],