SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
14604992 G41 Human NO
16288006 A24, MvLu1, FaDu Human NO
17699849 MON, STA-WT1, HeLa, SF268, 293T Kidney, Brain Human NO
28716547 HaCaT, GLL19 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25009291 CHLA-2-ATRT, CHLA-4-ATRT, BT12, BT37 AT/RT Brain Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
RNA polymerase I transcriptional preinitiation complex assembly [GO:0001188],
DNA repair [GO:0006281],
nucleosome disassembly [GO:0006337],
chromatin remodeling [GO:0006338],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
cell cycle [GO:0007049],
nervous system development [GO:0007399],
DNA integration [GO:0015074],
single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692],
ATP-dependent chromatin remodeling [GO:0043044],
positive regulation by host of viral transcription [GO:0043923],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of histone H4 acetylation [GO:0090240],
negative regulation of histone H3-K9 dimethylation [GO:1900110],
negative regulation of histone H3-K9 trimethylation [GO:1900113],
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838],
positive regulation of glucose mediated signaling pathway [GO:1902661],
positive regulation of histone H3-K9 acetylation [GO:2000617],
regulation of histone H4-K16 acetylation [GO:2000618],
blastocyst development [GO:0001824],
blastocyst hatching [GO:0001835],
chromatin organization [GO:0006325],
negative regulation of cell proliferation [GO:0008285],
cell differentiation [GO:0030154],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase I CORE element sequence-specific DNA binding [GO:0001164],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
Tat protein binding [GO:0030957],
nucleosomal DNA binding [GO:0031492],

Cellular Component:
nuclear chromatin [GO:0000790],
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
SWI/SNF complex [GO:0016514],
macromolecular complex [GO:0032991],
brahma complex [GO:0035060],
intracellular membrane-bounded organelle [GO:0043231],
npBAF complex [GO:0071564],
nBAF complex [GO:0071565],
nuclear chromosome [GO:0000228],
XY body [GO:0001741],
SWI/SNF superfamily-type complex [GO:0070603],