SMAD3

SMAD family member 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
12839923 Primary keratinocytes derived from skin Mouse NO
26936960 MEF, primary pancreatic islets derived from pancreas Pancreas Human, mouse NO
27892764 Primary mammary epithelial cells derived from breast Human NO
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
31085244 A549,U2OS Human NO
31155496 Primary β cells derived from pancreas Mouse YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33324644 RPE Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
ureteric bud development [GO:0001657],
response to hypoxia [GO:0001666],
in utero embryonic development [GO:0001701],
mesoderm formation [GO:0001707],
somitogenesis [GO:0001756],
liver development [GO:0001889],
heart looping [GO:0001947],
osteoblast development [GO:0002076],
immune system development [GO:0002520],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
immune response [GO:0006955],
cell cycle arrest [GO:0007050],
transforming growth factor beta receptor signaling pathway [GO:0007179],
SMAD protein complex assembly [GO:0007183],
endoderm development [GO:0007492],
embryonic pattern specification [GO:0009880],
positive regulation of gene expression [GO:0010628],
positive regulation of alkaline phosphatase activity [GO:0010694],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
regulation of striated muscle tissue development [GO:0016202],
protein deubiquitination [GO:0016579],
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015],
signal transduction involved in regulation of gene expression [GO:0023019],
negative regulation of cell growth [GO:0030308],
adrenal gland development [GO:0030325],
positive regulation of cell migration [GO:0030335],
positive regulation of bone mineralization [GO:0030501],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
thyroid gland development [GO:0030878],
primary miRNA processing [GO:0031053],
positive regulation of chondrocyte differentiation [GO:0032332],
positive regulation of interleukin-1 beta production [GO:0032731],
regulation of transforming growth factor beta2 production [GO:0032909],
positive regulation of transforming growth factor beta3 production [GO:0032916],
activin receptor signaling pathway [GO:0032924],
negative regulation of osteoblast proliferation [GO:0033689],
nodal signaling pathway [GO:0038092],
wound healing [GO:0042060],
T cell activation [GO:0042110],
negative regulation of protein catabolic process [GO:0042177],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of apoptotic process [GO:0043066],
cell-cell junction organization [GO:0045216],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of osteoblast differentiation [GO:0045668],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of mitotic cell cycle [GO:0045930],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
paraxial mesoderm morphogenesis [GO:0048340],
developmental growth [GO:0048589],
embryonic foregut morphogenesis [GO:0048617],
embryonic cranial skeleton morphogenesis [GO:0048701],
regulation of epithelial cell proliferation [GO:0050678],
negative regulation of inflammatory response [GO:0050728],
regulation of immune response [GO:0050776],
protein stabilization [GO:0050821],
positive regulation of positive chemotaxis [GO:0050927],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
regulation of binding [GO:0051098],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of focal adhesion assembly [GO:0051894],
pericardium development [GO:0060039],
transdifferentiation [GO:0060290],
SMAD protein signal transduction [GO:0060395],
negative regulation of wound healing [GO:0061045],
negative regulation of lung blood pressure [GO:0061767],
lens fiber cell differentiation [GO:0070306],
cellular response to cytokine stimulus [GO:0071345],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
extrinsic apoptotic signaling pathway [GO:0097191],
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296],
positive regulation of extracellular matrix assembly [GO:1901203],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243],
skeletal system development [GO:0001501],
osteoblast differentiation [GO:0001649],
regulation of transcription, DNA-templated [GO:0006355],
transcription from RNA polymerase II promoter [GO:0006366],
gastrulation [GO:0007369],
negative regulation of cell proliferation [GO:0008285],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
RNA polymerase II activating transcription factor binding [GO:0001102],
transcription coactivator binding [GO:0001223],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription cofactor activity [GO:0003712],
transforming growth factor beta receptor binding [GO:0005160],
protein binding [GO:0005515],
collagen binding [GO:0005518],
beta-catenin binding [GO:0008013],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
DEAD/H-box RNA helicase binding [GO:0017151],
protein kinase binding [GO:0019901],
phosphatase binding [GO:0019902],
chromatin DNA binding [GO:0031490],
ubiquitin protein ligase binding [GO:0031625],
mineralocorticoid receptor binding [GO:0031962],
glucocorticoid receptor binding [GO:0035259],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ubiquitin binding [GO:0043130],
bHLH transcription factor binding [GO:0043425],
sequence-specific DNA binding [GO:0043565],
co-SMAD binding [GO:0070410],
R-SMAD binding [GO:0070412],
primary miRNA binding [GO:0070878],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
double-stranded DNA binding [GO:0003690],
enzyme binding [GO:0019899],
SMAD binding [GO:0046332],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nuclear inner membrane [GO:0005637],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
receptor complex [GO:0043235],
SMAD protein complex [GO:0071141],
SMAD2-SMAD3 protein complex [GO:0071144],
intracellular [GO:0005622],
macromolecular complex [GO:0032991],