SLIT2

slit guidance ligand 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
ureteric bud development [GO:0001657],
negative regulation of protein phosphorylation [GO:0001933],
cell migration involved in sprouting angiogenesis [GO:0002042],
negative regulation of leukocyte chemotaxis [GO:0002689],
aortic valve morphogenesis [GO:0003180],
pulmonary valve morphogenesis [GO:0003184],
axon guidance [GO:0007411],
motor neuron axon guidance [GO:0008045],
negative regulation of lamellipodium assembly [GO:0010593],
negative regulation of endothelial cell migration [GO:0010596],
negative regulation of smooth muscle cell migration [GO:0014912],
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration [GO:0021834],
chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836],
corticospinal neuron axon guidance through spinal cord [GO:0021972],
negative regulation of cell growth [GO:0030308],
negative regulation of cell migration [GO:0030336],
negative regulation of actin filament polymerization [GO:0030837],
retinal ganglion cell axon guidance [GO:0031290],
cellular response to hormone stimulus [GO:0032870],
negative regulation of GTPase activity [GO:0034260],
Roundabout signaling pathway [GO:0035385],
positive regulation of apoptotic process [GO:0043065],
negative regulation of vascular permeability [GO:0043116],
branching morphogenesis of an epithelial tube [GO:0048754],
axon extension involved in axon guidance [GO:0048846],
positive regulation of axonogenesis [GO:0050772],
negative chemotaxis [GO:0050919],
induction of negative chemotaxis [GO:0050929],
negative regulation of small GTPase mediated signal transduction [GO:0051058],
response to cortisol [GO:0051414],
ventricular septum morphogenesis [GO:0060412],
apoptotic process involved in luteolysis [GO:0061364],
negative regulation of chemokine-mediated signaling pathway [GO:0070100],
cellular response to heparin [GO:0071504],
negative regulation of smooth muscle cell chemotaxis [GO:0071672],
negative regulation of mononuclear cell migration [GO:0071676],
negative regulation of neutrophil chemotaxis [GO:0090024],
negative regulation of monocyte chemotaxis [GO:0090027],
negative regulation of retinal ganglion cell axon guidance [GO:0090260],
negative regulation of cellular response to growth factor stimulus [GO:0090288],
metanephros development [GO:0001656],
in utero embryonic development [GO:0001701],
chemotaxis [GO:0006935],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
axonogenesis [GO:0007409],
negative regulation of cell proliferation [GO:0008285],
negative regulation of gene expression [GO:0010629],
olfactory bulb development [GO:0021772],
telencephalon cell migration [GO:0022029],
cell differentiation [GO:0030154],
negative regulation of axon extension [GO:0030517],
dorsal/ventral axon guidance [GO:0033563],
neuron projection morphogenesis [GO:0048812],
negative regulation of inflammatory response [GO:0050728],
mammary gland duct morphogenesis [GO:0060603],
mammary duct terminal end bud growth [GO:0060763],
cell-cell adhesion [GO:0098609],

Molecular Function:
GTPase inhibitor activity [GO:0005095],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
heparin binding [GO:0008201],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
laminin-1 binding [GO:0043237],
proteoglycan binding [GO:0043394],
Roundabout binding [GO:0048495],
receptor binding [GO:0005102],
extracellular matrix structural constituent [GO:0005201],
heparan sulfate proteoglycan binding [GO:0043395],
chemorepellent activity [GO:0045499],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
extracellular exosome [GO:0070062],
cell surface [GO:0009986],