solute carrier family 9 member A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
ion transport [GO:0006811],
cellular sodium ion homeostasis [GO:0006883],
regulation of pH [GO:0006885],
response to acidic pH [GO:0010447],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882],
cell migration [GO:0016477],
maintenance of cell polarity [GO:0030011],
hyaluronan catabolic process [GO:0030214],
positive regulation of cell growth [GO:0030307],
cellular response to insulin stimulus [GO:0032869],
positive regulation of mitochondrial membrane permeability [GO:0035794],
response to muscle stretch [GO:0035994],
sodium ion export from cell [GO:0036376],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of action potential [GO:0045760],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein oligomerization [GO:0051259],
regulation of intracellular pH [GO:0051453],
regulation of stress fiber assembly [GO:0051492],
regulation of focal adhesion assembly [GO:0051893],
regulation of sensory perception of pain [GO:0051930],
cardiac muscle cell differentiation [GO:0055007],
cellular response to cold [GO:0070417],
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886],
neuron death [GO:0070997],
cellular response to antibiotic [GO:0071236],
cellular response to electrical stimulus [GO:0071257],
cellular response to mechanical stimulus [GO:0071260],
cellular response to hypoxia [GO:0071456],
cellular response to acidic pH [GO:0071468],
potassium ion transmembrane transport [GO:0071805],
cellular response to epinephrine stimulus [GO:0071872],
cardiac muscle cell contraction [GO:0086003],
regulation of cardiac muscle cell membrane potential [GO:0086036],
regulation of the force of heart contraction by cardiac conduction [GO:0086092],
anion transmembrane transport [GO:0098656],
sodium ion import across plasma membrane [GO:0098719],
positive regulation of the force of heart contraction [GO:0098735],
hydrogen ion transmembrane transport [GO:1902600],
positive regulation of calcium:sodium antiporter activity [GO:1903281],
regulation of the force of heart contraction [GO:0002026],
cation transport [GO:0006812],
sodium ion transport [GO:0006814],
embryo development [GO:0009790],
response to organic cyclic compound [GO:0014070],
transmembrane transport [GO:0055085],
positive regulation of intracellular signal transduction [GO:1902533],

Molecular Function:
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
solute:proton antiporter activity [GO:0015299],
sodium:proton antiporter activity [GO:0015385],
potassium:proton antiporter activity [GO:0015386],
protein phosphatase 2B binding [GO:0030346],
protein binding, bridging [GO:0030674],
calcium-dependent protein binding [GO:0048306],
binding, bridging [GO:0060090],
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086040],
antiporter activity [GO:0015297],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
intercalated disc [GO:0014704],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
T-tubule [GO:0030315],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
cation-transporting ATPase complex [GO:0090533],
membrane [GO:0016020],
sarcolemma [GO:0042383],