SLC8A1

solute carrier family 8 member A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

GO terms:

Biological Process:
regulation of the force of heart contraction [GO:0002026],
regulation of heart rate [GO:0002027],
regulation of sodium ion transport [GO:0002028],
ion transport [GO:0006811],
cellular calcium ion homeostasis [GO:0006874],
cellular sodium ion homeostasis [GO:0006883],
muscle contraction [GO:0006936],
response to glucose [GO:0009749],
regulation of gene expression [GO:0010468],
regulation of cell communication by electrical coupling [GO:0010649],
positive regulation of fibroblast migration [GO:0010763],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882],
vascular smooth muscle contraction [GO:0014829],
telencephalon development [GO:0021537],
positive regulation of bone mineralization [GO:0030501],
response to ATP [GO:0033198],
sodium ion transmembrane transport [GO:0035725],
response to immobilization stress [GO:0035902],
response to muscle stretch [GO:0035994],
sodium ion export from cell [GO:0036376],
response to hydrogen peroxide [GO:0042542],
relaxation of smooth muscle [GO:0044557],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
cardiac muscle cell development [GO:0055013],
calcium ion homeostasis [GO:0055074],
relaxation of cardiac muscle [GO:0055119],
cardiac muscle contraction [GO:0060048],
cytosolic calcium ion transport [GO:0060401],
calcium ion transport into cytosol [GO:0060402],
calcium ion import [GO:0070509],
calcium ion transmembrane transport [GO:0070588],
cellular response to caffeine [GO:0071313],
cellular response to cAMP [GO:0071320],
cellular response to hypoxia [GO:0071456],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
sodium ion import across plasma membrane [GO:0098719],
positive regulation of the force of heart contraction [GO:0098735],
regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566],
regulation of cardiac conduction [GO:1903779],
response to hypoxia [GO:0001666],
embryonic placenta development [GO:0001892],
heart morphogenesis [GO:0003007],
sodium ion transport [GO:0006814],
calcium ion transport [GO:0006816],
cell communication [GO:0007154],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
post-embryonic development [GO:0009791],
cellular response to reactive oxygen species [GO:0034614],
embryonic heart tube development [GO:0035050],
muscle fiber development [GO:0048747],
regulation of calcium ion transport [GO:0051924],
transmembrane transport [GO:0055085],
regulation of cardiac muscle cell membrane potential [GO:0086036],
calcium ion export [GO:1901660],

Molecular Function:
calcium:sodium antiporter activity [GO:0005432],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
cytoskeletal protein binding [GO:0008092],
ankyrin binding [GO:0030506],
ion channel binding [GO:0044325],
ion antiporter activity involved in regulation of postsynaptic membrane potential [GO:0099580],
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060],
antiporter activity [GO:0015297],
metal ion binding [GO:0046872],
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086038],

Cellular Component:
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
postsynaptic density [GO:0014069],
intercalated disc [GO:0014704],
Z disc [GO:0030018],
T-tubule [GO:0030315],
axon [GO:0030424],
dendrite [GO:0030425],
sarcolemma [GO:0042383],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
axon terminus [GO:0043679],
synapse [GO:0045202],
cell periphery [GO:0071944],
integral component of postsynaptic membrane [GO:0099055],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
cell projection [GO:0042995],
postsynaptic membrane [GO:0045211],