ACHE

acetylcholinesterase (Cartwright blood group)

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
acetylcholine catabolic process in synaptic cleft [GO:0001507],
regulation of receptor recycling [GO:0001919],
osteoblast development [GO:0002076],
acetylcholine catabolic process [GO:0006581],
phosphatidylcholine biosynthetic process [GO:0006656],
cell adhesion [GO:0007155],
nervous system development [GO:0007399],
synapse assembly [GO:0007416],
receptor internalization [GO:0031623],
negative regulation of synaptic transmission, cholinergic [GO:0032223],
neurotransmitter biosynthetic process [GO:0042136],
amyloid precursor protein metabolic process [GO:0042982],
neurotransmitter receptor biosynthetic process [GO:0045212],
positive regulation of protein secretion [GO:0050714],
retina development in camera-type eye [GO:0060041],
acetylcholine metabolic process [GO:0008291],
choline metabolic process [GO:0019695],
neurotransmitter catabolic process [GO:0042135],
positive regulation of axonogenesis [GO:0050772],
positive regulation of dendrite morphogenesis [GO:0050775],
neuron death [GO:0070997],

Molecular Function:
beta-amyloid binding [GO:0001540],
acetylcholinesterase activity [GO:0003990],
cholinesterase activity [GO:0004104],
protein binding [GO:0005515],
collagen binding [GO:0005518],
hydrolase activity [GO:0016787],
serine hydrolase activity [GO:0017171],
acetylcholine binding [GO:0042166],
protein homodimerization activity [GO:0042803],
laminin binding [GO:0043236],
protein self-association [GO:0043621],
carboxylic ester hydrolase activity [GO:0052689],
choline binding [GO:0033265],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
extracellular space [GO:0005615],
nucleus [GO:0005634],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
anchored component of membrane [GO:0031225],
neuromuscular junction [GO:0031594],
synaptic cleft [GO:0043083],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
rough endoplasmic reticulum [GO:0005791],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
presynaptic membrane [GO:0042734],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
postsynaptic membrane [GO:0045211],