SIRT7

sirtuin 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23342163 HMEC, HUVEC, BREC Human, cow NO
23680022 TIG-3, WI-38 Human NO
24885964 MCF7 Human NO
26991832 Primary dental pulp stem cells derived from third molar Dental pulp Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
osteoblast differentiation [GO:0001649],
regulation of gluconeogenesis [GO:0006111],
DNA repair [GO:0006281],
regulation of DNA repair [GO:0006282],
protein deacetylation [GO:0006476],
cellular response to DNA damage stimulus [GO:0006974],
positive regulation of transcription involved in exit from mitosis [GO:0007072],
synapsis [GO:0007129],
rRNA transcription [GO:0009303],
negative regulation of transposition [GO:0010529],
regulation of mitochondrion organization [GO:0010821],
histone modification [GO:0016570],
negative regulation of protein ubiquitination [GO:0031397],
peptidyl-lysine desuccinylation [GO:0036049],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of protein export from nucleus [GO:0046825],
protein deglutarylation [GO:0061698],
peptidyl-lysine deglutarylation [GO:0061699],
histone H3 deacetylation [GO:0070932],
histone H4 deacetylation [GO:0070933],
regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901836],
histone glutamine methylation [GO:1990258],
positive regulation of rRNA processing [GO:2000234],
regulation of double-strand break repair via nonhomologous end joining [GO:2001032],
chromatin organization [GO:0006325],

Molecular Function:
chromatin binding [GO:0003682],
transcription corepressor activity [GO:0003714],
histone deacetylase activity [GO:0004407],
protein binding [GO:0005515],
deacetylase activity [GO:0019213],
NAD-dependent protein deacetylase activity [GO:0034979],
protein-succinyllysine desuccinylase activity [GO:0036055],
metal ion binding [GO:0046872],
protein-glutaryllysine deglutarylase activity [GO:0061697],
NAD+ binding [GO:0070403],
NAD-dependent histone deacetylase activity (H3-K18 specific) [GO:0097372],
transferase activity [GO:0016740],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
nucleolus organizer region [GO:0005731],
cytoplasm [GO:0005737],
site of double-strand break [GO:0035861],
chromosome [GO:0005694],