BECN1

beclin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
27462784 T-47-D, MCF7 Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30693443 Cochlea Mouse NO
31945125 Primary astrocytes derived from brain Human YES
32109516 Brain Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29991800 U87 Human NO
30807795 HT-22 Mouse NO
30894058 RAW 264.7 Mouse NO
31469660 Primary neurons derived from brain Rat NO
31559522 Primary cells derived from periodontium Human NO
31881006 Primary mesenchymal stells derived from bone marrow Human,rat NO
31885770 Primary mesenchymal stells derived from adipose tissue Human NO
32047439 Primary endothelial progenitor cells isolated from bone marrow Rat NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
macromitophagy [GO:0000423],
endocytosis [GO:0006897],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
cellular defense response [GO:0006968],
cellular response to nitrogen starvation [GO:0006995],
mitotic metaphase plate congression [GO:0007080],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
viral process [GO:0016032],
macroautophagy [GO:0016236],
protein deubiquitination [GO:0016579],
CVT pathway [GO:0032258],
regulation of cytokinesis [GO:0032465],
receptor catabolic process [GO:0032801],
cellular response to glucose starvation [GO:0042149],
negative regulation of apoptotic process [GO:0043066],
early endosome to late endosome transport [GO:0045022],
late endosome to vacuole transport [GO:0045324],
cell division [GO:0051301],
defense response to virus [GO:0051607],
negative regulation of cell death [GO:0060548],
response to mitochondrial depolarisation [GO:0098780],
positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
angiogenesis [GO:0001525],
lysosome organization [GO:0007040],
cell cycle [GO:0007049],
negative regulation of cell proliferation [GO:0008285],
negative regulation of autophagy [GO:0010507],
positive regulation of autophagy [GO:0010508],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
engulfment of apoptotic cell [GO:0043652],
neuron development [GO:0048666],
beta-amyloid metabolic process [GO:0050435],
regulation of catalytic activity [GO:0050790],
response to other organism [GO:0051707],
negative regulation of autophagosome assembly [GO:1902902],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
positive regulation of autophagosome assembly [GO:2000786],

Molecular Function:
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
phosphatidylinositol 3-kinase binding [GO:0043548],
GTPase binding [GO:0051020],
identical protein binding [GO:0042802],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
nucleus [GO:0005634],
mitochondrion [GO:0005739],
endosome [GO:0005768],
autophagosome [GO:0005776],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
endosome membrane [GO:0010008],
extrinsic component of membrane [GO:0019898],
mitochondrial membrane [GO:0031966],
phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271],
phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272],
phosphatidylinositol 3-kinase complex, class III [GO:0035032],
cytoplasm [GO:0005737],
trans-Golgi network [GO:0005802],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
dendrite [GO:0030425],
cytoplasmic vesicle [GO:0031410],
macromolecular complex [GO:0032991],
phagocytic vesicle [GO:0045335],