SIRT1

sirtuin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16054100 MEF Mouse NO
25664004 AGS, MKN-45 Human NO
30788732 2BS Human NO
31461302 16HBE Lung Human, mouse NO
31970335 VSMC Human NO
32148417 HDF Human NO
32158519 HUVEC Human NO
32989246 IMR90 Spleen, Testis Human, Mouse NO
31792920 HUVEC Human NO
33111210 Primary dermal fibroblasts Human NO
32558394 HEK293T Human NO
32558394 HEK293T Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16170353 MCF7, NCI-H1299 Human NO
17916362 HUVEC Human NO
18320031 2BS, WI-38 Human NO
18556572 HUVEC Artery Human, mouse NO
19286634 HUVEC Artery Human, mouse NO
19377286 PC3 Human NO
19716821 Primary vascular smooth muscle cells derived from thoracic artery Human NO
19786632 HUVEC, HAEC, HCAEC Artery Human NO
19887452 Primary chondrocytes derived isolated from cartilage Rabbit NO
20203304 Primary aortic cells derived from heart Artery Pig NO
20493163 NCI-H292, HFL1, Mono-Mac-6 Lung Human, mouse NO
20627091 HUVEC Heart, Spleen Human, mouse NO
20705918 HUVEC Mouse NO
20813124 WI38, MRC-5 Kidney Human, rat NO
21088277 HUVEC Human NO
21169404 Primary bone marrow mononuclear cells derived from blood, EPCs Mouse NO
21390332 WI-38, IMR-90, MRC-5 Lung Human NO
21471201 A431 Skin Human, mouse NO
21527554 HepG2, SK-Hep-1, PLC5, Hep3B, SNU-449, SNU-423, Huh7, HKCI-4, HKCI-2, HEK 293FT Liver Human NO
21719763 HASMC Artery Human, rat NO
22038097 Primary mesenchymal stem cells derived from bone marrow, Primary mesenchymal stem cells derived from adipose tissue Human NO
22190494 P493-6, TGR-1, HO15.19, U2OS, MCF7, MEF, HDF Human, mouse NO
22197555 HUC-F2 Human NO
22238626 HUVEC Brain, Testis Human, mouse NO
22510478 WS1, TIG-1 Human NO
22546858 Lung Human, mouse NO
22561310 Primary mesangial cells derived from kidney Rat NO
22744176 Artery Mouse NO
Primary porcine aortic endothelial cells drived from heart
23056314 HUVEC, HAEC Human NO
23342163 HMEC, EBM-2, HUVEC Eye, Kidney human NO
23727633 Primary tenocytes derived from tendon Tendon  Human NO
23827175 HepG2, Primary hepatocytes derived from Liver Human, mouse NO
23897750 Primary mononuclear cells derived from blood, HUVEC Human NO
24372553 MMECs Mouse NO
24518759 Primary endothelial colony-forming cells derived from cord blood Mouse NO
24729176 HUVEC Human NO
24742694 51-mel, 125Lu, A375, WM9, SBCL2 SK-MEL-28, M14 Human NO
24917814 Primary mesenchymal stem cells derived from bone marrow Rat NO
24952428 Primary podocytes derived from kidney Kidney Mouse NO
24973384 VSMC Human NO
25000517 HUC-F2 Human NO
25040736 HUVEC, Primary endothelial cells derived from umbilical cord veins Artery Human, mouse NO
25070626 U2OS, MCF7, IMR-90, HCT 116, A549, MEF Human, mouse NO
25165029 HS27 Skin Mouse NO
25189993 LNCaP, PC3, Ramos, Jurkat, NCI-H1299, MRC-5, H46, A549, ZR-75, MDA-MB-231 Human NO
25243179 Primary mesenchymal stem cells derived from bone marrow Human NO
25299185 VSMC Human NO
25352462 HASM Artery Human, mouse NO
25386949 HUVEC Human NO
25512378 MEF Mouse NO
25557355 LNCaP, DU 145, HEK-293 Prostate gland Human NO
25635860 MRC-5, BJ Human NO
25924011 BJ Human NO
25975679 Primary mesenchymal stem cells derived from bone marrow Human NO
26934321 MCF7, T-47D Breast Human, mouse NO
26940203 Primary cartilage end plates cells Cartilage end plates Human NO
27101740 Primary endothelial cells derived from pulmonary artery endothelium Human NO
27259994 VSMC Mouse NO
27277186 EPCs Human NO
27339462 VSMC Artery Mouse, rat NO
27340387 U251, SNB-75, U-87MG Human NO
27349869 Primary keratinocytes derived from skin Human NO
27354409 Primary mononuclear cells derived from peripheral blood , CD4+ T cells derived from peripheral blood Human NO
27559927 HFL1, SAECs Lung Human, mouse NO
27569277 EPCs Mouse NO
27582325 WI38 Kidney Human, mouse NO
27650558 VSMC Artery Mouse NO
28331525 HUVEC Blood Human NO
28339869 MSC Bone marrow Human NO
28475330 U373, Hs683 Human NO
28514055 HDFs, A549, HCT 116, MEF, H46 Human, mouse NO
28544111 Primary endothelial progenitor cells derived from blood Artery Human, mouse NO
28726780 BEAS-2B, IMR-90 Esophagus Mouse NO
28751929 HDFs, BEAS-2B Human NO
Primary dermal fibroblasts derived from foreskin
29678576 Primary mesenchymal stem cells derived from adipose tissue Adipose Human NO
30002688 HUVEC Human NO
30105071 HUVEC Human NO
30554563 HUVEC, EPCs Artery Human, mouse NO
30666570 Primary fibroblasts derived from skin Human NO
30696833 VSMC Human NO
30717449 EPCs, primary mesenchymal stem cells derived from bone marrow Mouse NO
30789795 Primary smooth muscle cells derived from artery Rat NO
30928680 3T3-L1 Mouse NO
31074095 Primary fibroblasts derived from skin Îœouse NO
31182679 HUVEC Human NO
31443378 Primary endothelial cells derived from retina Human NO
31481873 HT22 Mouse NO
31503007 SMMC-7721, Hep G2 Human NO
31551807 Heart Mouse NO
31552414 HMVEC Human NO
31612074 2BS Human NO
31633821 Primary melanocytes derived from skin Human NO
31704100 HUVEC, WI-38 Human NO
31750822 HUVEC Human NO
31752013 HUVEC Human NO
31792920 HUVEC Human NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31881011 A549 Human NO
31945125 Primary astrocytes derived from brain Human YES
32054948 A549, H460, H1299, MyLa, MJ Human NO
32109515 Brain Mouse NO
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord Human, rat No
32630570 HUVEC Human NO
32404543 HDF Human NO
32634429 Primary mesenchymal cells derived from adipose tissue Human NO
32665267 Cartilage Mouse NO
33038325 Primary neurons derived from brain Mouse No
32997729 VSMC Rat NO

GO terms:

Biological Process:
single strand break repair [GO:0000012],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
chromatin silencing at rDNA [GO:0000183],
pyrimidine dimer repair by nucleotide-excision repair [GO:0000720],
DNA synthesis involved in DNA repair [GO:0000731],
angiogenesis [GO:0001525],
ovulation from ovarian follicle [GO:0001542],
cellular glucose homeostasis [GO:0001678],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
positive regulation of adaptive immune response [GO:0002821],
chromatin organization [GO:0006325],
methylation-dependent chromatin silencing [GO:0006346],
protein ADP-ribosylation [GO:0006471],
protein deacetylation [GO:0006476],
triglyceride mobilization [GO:0006642],
cellular response to DNA damage stimulus [GO:0006974],
response to oxidative stress [GO:0006979],
transforming growth factor beta receptor signaling pathway [GO:0007179],
spermatogenesis [GO:0007283],
regulation of mitotic cell cycle [GO:0007346],
muscle organ development [GO:0007517],
cell aging [GO:0007569],
positive regulation of cell proliferation [GO:0008284],
cellular response to starvation [GO:0009267],
negative regulation of gene expression [GO:0010629],
positive regulation of cholesterol efflux [GO:0010875],
regulation of lipid storage [GO:0010883],
regulation of glucose metabolic process [GO:0010906],
macrophage cytokine production [GO:0010934],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
viral process [GO:0016032],
positive regulation of macroautophagy [GO:0016239],
protein ubiquitination [GO:0016567],
histone deacetylation [GO:0016575],
peptidyl-lysine acetylation [GO:0018394],
macrophage differentiation [GO:0030225],
negative regulation of cell growth [GO:0030308],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
negative regulation of prostaglandin biosynthetic process [GO:0031393],
heterochromatin assembly [GO:0031507],
protein destabilization [GO:0031648],
negative regulation of TOR signaling [GO:0032007],
regulation of endodeoxyribonuclease activity [GO:0032071],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
response to insulin [GO:0032868],
circadian regulation of gene expression [GO:0032922],
leptin-mediated signaling pathway [GO:0033210],
regulation of smooth muscle cell apoptotic process [GO:0034391],
peptidyl-lysine deacetylation [GO:0034983],
cellular triglyceride homeostasis [GO:0035356],
regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358],
regulation of cell proliferation [GO:0042127],
negative regulation of phosphorylation [GO:0042326],
response to hydrogen peroxide [GO:0042542],
behavioral response to starvation [GO:0042595],
cholesterol homeostasis [GO:0042632],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
response to leptin [GO:0044321],
positive regulation of MHC class II biosynthetic process [GO:0045348],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of gluconeogenesis [GO:0045722],
positive regulation of DNA repair [GO:0045739],
positive regulation of angiogenesis [GO:0045766],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of insulin receptor signaling pathway [GO:0046628],
white fat cell differentiation [GO:0050872],
negative regulation of helicase activity [GO:0051097],
positive regulation of smooth muscle cell differentiation [GO:0051152],
positive regulation of histone H3-K9 methylation [GO:0051574],
negative regulation of protein kinase B signaling [GO:0051898],
fatty acid homeostasis [GO:0055089],
negative regulation of androgen receptor signaling pathway [GO:0060766],
histone H3-K9 modification [GO:0061647],
cellular response to hydrogen peroxide [GO:0070301],
heterochromatin maintenance [GO:0070829],
regulation of bile acid biosynthetic process [GO:0070857],
UV-damage excision repair [GO:0070914],
histone H3 deacetylation [GO:0070932],
cellular response to tumor necrosis factor [GO:0071356],
negative regulation of histone H3-K14 acetylation [GO:0071441],
cellular response to hypoxia [GO:0071456],
cellular response to ionizing radiation [GO:0071479],
regulation of protein serine/threonine kinase activity [GO:0071900],
regulation of brown fat cell differentiation [GO:0090335],
stress-induced premature senescence [GO:0090400],
regulation of cellular response to heat [GO:1900034],
negative regulation of histone H3-K9 trimethylation [GO:1900113],
negative regulation of neuron death [GO:1901215],
negative regulation of protein acetylation [GO:1901984],
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166],
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176],
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237],
positive regulation of adipose tissue development [GO:1904179],
histone H3-K9 deacetylation [GO:1990619],
cellular response to leukemia inhibitory factor [GO:1990830],
positive regulation of macrophage apoptotic process [GO:2000111],
negative regulation of cAMP-dependent protein kinase activity [GO:2000480],
positive regulation of cAMP-dependent protein kinase activity [GO:2000481],
negative regulation of histone H4-K16 acetylation [GO:2000619],
negative regulation of cellular response to testosterone stimulus [GO:2000655],
negative regulation of peptidyl-lysine acetylation [GO:2000757],
negative regulation of cellular senescence [GO:2000773],
positive regulation of cellular senescence [GO:2000774],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
circadian rhythm [GO:0007623],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
positive regulation of heart rate [GO:0010460],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
positive regulation of neuron projection development [GO:0010976],
positive regulation of skeletal muscle cell proliferation [GO:0014858],
cell differentiation [GO:0030154],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
negative regulation of DNA binding [GO:0043392],
negative regulation of neuron apoptotic process [GO:0043524],
response to ethanol [GO:0045471],
rhythmic process [GO:0048511],
negative regulation of growth hormone secretion [GO:0060125],
negative regulation of cell death [GO:0060548],
positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051],
positive regulation of protein deacetylation [GO:0090312],
energy homeostasis [GO:0097009],
negative regulation of protein localization to nucleus [GO:1900181],
negative regulation of reactive oxygen species biosynthetic process [GO:1903427],
cellular response to beta-amyloid [GO:1904646],
negative regulation of fibroblast apoptotic process [GO:2000270],
positive regulation of thyroid-stimulating hormone secretion [GO:2000614],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
p53 binding [GO:0002039],
transcription coactivator activity [GO:0003713],
transcription corepressor activity [GO:0003714],
NAD+ ADP-ribosyltransferase activity [GO:0003950],
histone deacetylase activity [GO:0004407],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
transcription factor binding [GO:0008134],
NAD-dependent histone deacetylase activity [GO:0017136],
deacetylase activity [GO:0019213],
enzyme binding [GO:0019899],
protein deacetylase activity [GO:0033558],
NAD-dependent protein deacetylase activity [GO:0034979],
nuclear hormone receptor binding [GO:0035257],
histone binding [GO:0042393],
identical protein binding [GO:0042802],
HLH domain binding [GO:0043398],
bHLH transcription factor binding [GO:0043425],
metal ion binding [GO:0046872],
NAD-dependent histone deacetylase activity (H3-K9 specific) [GO:0046969],
mitogen-activated protein kinase binding [GO:0051019],
NAD+ binding [GO:0070403],
keratin filament binding [GO:1990254],
transferase activity [GO:0016740],
protein domain specific binding [GO:0019904],
protein kinase B binding [GO:0043422],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
nuclear inner membrane [GO:0005637],
nucleoplasm [GO:0005654],
chromatin silencing complex [GO:0005677],
nuclear euchromatin [GO:0005719],
nuclear heterochromatin [GO:0005720],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
PML body [GO:0016605],
rDNA heterochromatin [GO:0033553],
ESC/E(Z) complex [GO:0035098],
chromatin [GO:0000785],
axon [GO:0030424],
growth cone [GO:0030426],