SHPRH

SNF2 histone linker PHD RING helicase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA82 Skin, Lung Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
DNA repair [GO:0006281],
nucleosome assembly [GO:0006334],
cellular response to DNA damage stimulus [GO:0006974],
protein ubiquitination [GO:0016567],

Molecular Function:
DNA binding [GO:0003677],
helicase activity [GO:0004386],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ubiquitin protein ligase binding [GO:0031625],
metal ion binding [GO:0046872],
ubiquitin protein ligase activity [GO:0061630],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
hydrolase activity [GO:0016787],

Cellular Component:
nucleosome [GO:0000786],
nucleoplasm [GO:0005654],
host cell nucleus [GO:0042025],
cellular_component [GO:0005575],
nucleus [GO:0005634],