BCR

BCR activator of RhoGEF and GTPase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of cellular extravasation [GO:0002692],
renal system process [GO:0003014],
protein phosphorylation [GO:0006468],
signal transduction [GO:0007165],
small GTPase mediated signal transduction [GO:0007264],
brain development [GO:0007420],
actin cytoskeleton organization [GO:0030036],
keratinocyte differentiation [GO:0030216],
regulation of Rho protein signal transduction [GO:0035023],
inner ear morphogenesis [GO:0042472],
regulation of vascular permeability [GO:0043114],
negative regulation of neutrophil degranulation [GO:0043314],
protein autophosphorylation [GO:0046777],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
focal adhesion assembly [GO:0048041],
homeostasis of number of cells [GO:0048872],
negative regulation of inflammatory response [GO:0050728],
positive regulation of phagocytosis [GO:0050766],
modulation of synaptic transmission [GO:0050804],
neuromuscular process controlling balance [GO:0050885],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of nitrogen compound metabolic process [GO:0051171],
regulation of cell cycle [GO:0051726],
definitive hemopoiesis [GO:0060216],
negative regulation of respiratory burst [GO:0060268],
negative regulation of blood vessel remodeling [GO:0060313],
intracellular protein transmembrane transport [GO:0065002],
cellular response to lipopolysaccharide [GO:0071222],
activation of GTPase activity [GO:0090630],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
phosphorylation [GO:0016310],
negative regulation of cell migration [GO:0030336],
response to lipopolysaccharide [GO:0032496],
intracellular signal transduction [GO:0035556],
positive regulation of GTPase activity [GO:0043547],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
enzyme binding [GO:0019899],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
axon [GO:0030424],
macromolecular complex [GO:0032991],
dendritic spine [GO:0043197],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
cytoplasm [GO:0005737],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],