SHH

sonic hedgehog signaling molecule

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31080015 Primary stem cells derived from endometrium, primary stem cells derived from adipose tissue Blood, brain, kidney, liver,uterus Human, mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
patterning of blood vessels [GO:0001569],
vasculogenesis [GO:0001570],
metanephros development [GO:0001656],
branching involved in ureteric bud morphogenesis [GO:0001658],
cell fate specification [GO:0001708],
neural crest cell migration [GO:0001755],
heart looping [GO:0001947],
positive regulation of neuroblast proliferation [GO:0002052],
osteoblast development [GO:0002076],
lymphoid progenitor cell differentiation [GO:0002320],
determination of left/right asymmetry in lateral mesoderm [GO:0003140],
endocytosis [GO:0006897],
smoothened signaling pathway [GO:0007224],
positive regulation of hh target transcription factor activity [GO:0007228],
cell-cell signaling [GO:0007267],
pattern specification process [GO:0007389],
ectoderm development [GO:0007398],
neuroblast proliferation [GO:0007405],
axon guidance [GO:0007411],
central nervous system development [GO:0007417],
ventral midline development [GO:0007418],
hindgut morphogenesis [GO:0007442],
heart development [GO:0007507],
blood coagulation [GO:0007596],
androgen metabolic process [GO:0008209],
positive regulation of cell proliferation [GO:0008284],
embryonic pattern specification [GO:0009880],
polarity specification of anterior/posterior axis [GO:0009949],
dorsal/ventral pattern formation [GO:0009953],
regulation of gene expression [GO:0010468],
oligodendrocyte development [GO:0014003],
striated muscle tissue development [GO:0014706],
positive regulation of skeletal muscle cell proliferation [GO:0014858],
myotube differentiation [GO:0014902],
intein-mediated protein splicing [GO:0016539],
protein autoprocessing [GO:0016540],
spinal cord dorsal/ventral patterning [GO:0021513],
spinal cord motor neuron differentiation [GO:0021522],
thalamus development [GO:0021794],
dorsal/ventral neural tube patterning [GO:0021904],
cerebellar granule cell precursor proliferation [GO:0021930],
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938],
telencephalon regionalization [GO:0021978],
establishment of cell polarity [GO:0030010],
regulation of proteolysis [GO:0030162],
positive regulation of Wnt signaling pathway [GO:0030177],
lung development [GO:0030324],
embryonic limb morphogenesis [GO:0030326],
negative regulation of cell migration [GO:0030336],
male genitalia development [GO:0030539],
prostate gland development [GO:0030850],
thyroid gland development [GO:0030878],
forebrain development [GO:0030900],
midbrain development [GO:0030901],
hindbrain development [GO:0030902],
pancreas development [GO:0031016],
hair follicle morphogenesis [GO:0031069],
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435],
T cell differentiation in thymus [GO:0033077],
positive regulation of T cell differentiation in thymus [GO:0033089],
positive regulation of immature T cell proliferation in thymus [GO:0033092],
negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244],
protein localization to nucleus [GO:0034504],
embryonic forelimb morphogenesis [GO:0035115],
embryonic hindlimb morphogenesis [GO:0035116],
regulation of cell proliferation [GO:0042127],
negative regulation of T cell proliferation [GO:0042130],
positive regulation of protein import into nucleus [GO:0042307],
odontogenesis of dentin-containing tooth [GO:0042475],
regulation of odontogenesis [GO:0042481],
embryonic digit morphogenesis [GO:0042733],
camera-type eye development [GO:0043010],
negative regulation of apoptotic process [GO:0043066],
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369],
positive thymic T cell selection [GO:0045059],
negative thymic T cell selection [GO:0045060],
intermediate filament organization [GO:0045109],
myoblast differentiation [GO:0045445],
negative regulation of cell differentiation [GO:0045596],
positive regulation of smoothened signaling pathway [GO:0045880],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of alpha-beta T cell differentiation [GO:0046638],
negative regulation of alpha-beta T cell differentiation [GO:0046639],
cell development [GO:0048468],
thymus development [GO:0048538],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic foregut morphogenesis [GO:0048617],
positive regulation of skeletal muscle tissue development [GO:0048643],
animal organ formation [GO:0048645],
neuron fate commitment [GO:0048663],
embryonic skeletal system development [GO:0048706],
oligodendrocyte differentiation [GO:0048709],
positive regulation of oligodendrocyte differentiation [GO:0048714],
smooth muscle tissue development [GO:0048745],
branching morphogenesis of an epithelial tube [GO:0048754],
inner ear development [GO:0048839],
formation of anatomical boundary [GO:0048859],
stem cell development [GO:0048864],
positive regulation of striated muscle cell differentiation [GO:0051155],
positive regulation of cell division [GO:0051781],
Bergmann glial cell differentiation [GO:0060020],
palate development [GO:0060021],
canonical Wnt signaling pathway [GO:0060070],
limb bud formation [GO:0060174],
lung epithelium development [GO:0060428],
trachea morphogenesis [GO:0060439],
branching involved in salivary gland morphogenesis [GO:0060445],
bud outgrowth involved in lung branching [GO:0060447],
right lung development [GO:0060458],
left lung development [GO:0060459],
lung lobe morphogenesis [GO:0060463],
lung-associated mesenchyme development [GO:0060484],
primary prostatic bud elongation [GO:0060516],
prostate epithelial cord elongation [GO:0060523],
salivary gland cavitation [GO:0060662],
epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664],
regulation of prostatic bud formation [GO:0060685],
epithelial-mesenchymal signaling involved in prostate gland development [GO:0060738],
positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769],
regulation of mesenchymal cell proliferation involved in prostate gland development [GO:0060782],
mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783],
artery development [GO:0060840],
mesenchymal cell proliferation involved in lung development [GO:0060916],
somite development [GO:0061053],
positive regulation of sclerotome development [GO:0061189],
cellular response to lithium ion [GO:0071285],
dopaminergic neuron differentiation [GO:0071542],
metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136],
metanephric collecting duct development [GO:0072205],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
negative regulation of cholesterol efflux [GO:0090370],
apoptotic signaling pathway [GO:0097190],
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900175],
regulation of protein localization to nucleus [GO:1900180],
negative regulation of dopaminergic neuron differentiation [GO:1904339],
tracheoesophageal septum formation [GO:1905327],
negative regulation of ureter smooth muscle cell differentiation [GO:2000062],
positive regulation of ureter smooth muscle cell differentiation [GO:2000063],
negative regulation of kidney smooth muscle cell differentiation [GO:2000357],
positive regulation of kidney smooth muscle cell differentiation [GO:2000358],
positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729],
negative regulation of mesenchymal cell apoptotic process [GO:2001054],
angiogenesis [GO:0001525],
kidney development [GO:0001822],
neural tube formation [GO:0001841],
hair follicle development [GO:0001942],
vasculature development [GO:0001944],
positive regulation of mesenchymal cell proliferation [GO:0002053],
regulation of transcription, DNA-templated [GO:0006355],
proteolysis [GO:0006508],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],
determination of left/right symmetry [GO:0007368],
digestive tract mesoderm development [GO:0007502],
cell proliferation [GO:0008283],
embryo development [GO:0009790],
anterior/posterior pattern specification [GO:0009952],
mesenchymal cell proliferation [GO:0010463],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
ventral spinal cord interneuron specification [GO:0021521],
forebrain regionalization [GO:0021871],
cell proliferation in external granule layer [GO:0021924],
positive regulation of cerebellar granule cell precursor proliferation [GO:0021940],
zona limitans intrathalamica formation [GO:0022006],
negative regulation of Wnt signaling pathway [GO:0030178],
respiratory tube development [GO:0030323],
positive regulation of neurotrophin production [GO:0032901],
negative regulation of protein catabolic process [GO:0042177],
odontogenesis [GO:0042476],
tongue development [GO:0043586],
tongue morphogenesis [GO:0043587],
skin development [GO:0043588],
cell fate commitment [GO:0045165],
response to ethanol [GO:0045471],
positive regulation of cell differentiation [GO:0045597],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of photoreceptor cell differentiation [GO:0046534],
digestive tract morphogenesis [GO:0048546],
embryonic organ development [GO:0048568],
developmental growth [GO:0048589],
embryonic morphogenesis [GO:0048598],
anatomical structure formation involved in morphogenesis [GO:0048646],
response to axon injury [GO:0048678],
male genitalia morphogenesis [GO:0048808],
anatomical structure development [GO:0048856],
striated muscle cell differentiation [GO:0051146],
limb development [GO:0060173],
positive regulation of penile erection [GO:0060406],
lung morphogenesis [GO:0060425],
trachea development [GO:0060438],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
branching involved in prostate gland morphogenesis [GO:0060442],
prostatic bud formation [GO:0060513],
epithelial-mesenchymal cell signaling [GO:0060684],
regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],
fungiform papilla development [GO:0061196],
fungiform papilla morphogenesis [GO:0061197],
fungiform papilla formation [GO:0061198],
positive regulation of oligodendrocyte progenitor proliferation [GO:0070447],
commissural neuron axon guidance [GO:0071679],
negative regulation of neuron death [GO:1901215],
positive regulation of sprouting angiogenesis [GO:1903672],
positive regulation of endothelial cell chemotaxis [GO:2001028],

Molecular Function:
patched binding [GO:0005113],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
glycosaminoglycan binding [GO:0005539],
peptidase activity [GO:0008233],
zinc ion binding [GO:0008270],
morphogen activity [GO:0016015],
laminin-1 binding [GO:0043237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane raft [GO:0045121],
nucleus [GO:0005634],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
synaptic vesicle [GO:0008021],
membrane [GO:0016020],
transport vesicle [GO:0030133],
axon [GO:0030424],
dendrite [GO:0030425],
extracellular matrix [GO:0031012],
neuronal cell body [GO:0043025],