SH3 domain binding protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
phagocytosis [GO:0006909],
phagocytosis, engulfment [GO:0006911],
actin filament organization [GO:0007015],
signal transduction [GO:0007165],
cell migration [GO:0016477],
regulation of actin filament depolymerization [GO:0030834],
regulation of actin cytoskeleton organization [GO:0032956],
cell junction assembly [GO:0034329],
regulation of Rac protein signal transduction [GO:0035020],
regulation of blood vessel endothelial cell migration [GO:0043535],
positive regulation of GTPase activity [GO:0043547],
establishment of epithelial cell apical/basal polarity [GO:0045198],
filopodium assembly [GO:0046847],
negative regulation of small GTPase mediated signal transduction [GO:0051058],
semaphorin-plexin signaling pathway [GO:0071526],
ruffle assembly [GO:0097178],

Molecular Function:
GTPase activator activity [GO:0005096],
SH3 domain binding [GO:0017124],
semaphorin receptor binding [GO:0030215],
Rac GTPase binding [GO:0048365],
protein binding [GO:0005515],

Cellular Component:
exocyst [GO:0000145],
phagocytic cup [GO:0001891],
intracellular [GO:0005622],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
adherens junction [GO:0005912],
bicellular tight junction [GO:0005923],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
cell leading edge [GO:0031252],
cell projection [GO:0042995],