ACE2

angiotensin I converting enzyme 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
regulation of cytokine production [GO:0001817],
angiotensin maturation [GO:0002003],
angiotensin-mediated drinking behavior [GO:0003051],
regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081],
tryptophan transport [GO:0015827],
regulation of vasoconstriction [GO:0019229],
receptor biosynthetic process [GO:0032800],
regulation of cell proliferation [GO:0042127],
viral entry into host cell [GO:0046718],
receptor-mediated virion attachment to host cell [GO:0046813],
regulation of inflammatory response [GO:0050727],
positive regulation of amino acid transport [GO:0051957],
positive regulation of cardiac muscle contraction [GO:0060452],
positive regulation of gap junction assembly [GO:1903598],
regulation of cardiac conduction [GO:1903779],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
proteolysis [GO:0006508],
negative regulation of smooth muscle cell proliferation [GO:0048662],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],

Molecular Function:
virus receptor activity [GO:0001618],
endopeptidase activity [GO:0004175],
carboxypeptidase activity [GO:0004180],
metallocarboxypeptidase activity [GO:0004181],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
peptidyl-dipeptidase activity [GO:0008241],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
brush border membrane [GO:0031526],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
membrane [GO:0016020],