sestrin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
regulation of protein phosphorylation [GO:0001932],
regulation of gluconeogenesis [GO:0006111],
fatty acid beta-oxidation [GO:0006635],
response to glucose [GO:0009749],
positive regulation of macroautophagy [GO:0016239],
negative regulation of cell growth [GO:0030308],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
mitochondrial DNA metabolic process [GO:0032042],
response to insulin [GO:0032868],
cellular response to amino acid starvation [GO:0034198],
cellular response to oxidative stress [GO:0034599],
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0036091],
cellular response to glucose starvation [GO:0042149],
glucose homeostasis [GO:0042593],
protein kinase B signaling [GO:0043491],
glucose import [GO:0046323],
triglyceride homeostasis [GO:0070328],
cellular response to amino acid stimulus [GO:0071230],
cellular response to leucine [GO:0071233],
reactive oxygen species metabolic process [GO:0072593],
cellular oxidant detoxification [GO:0098869],
positive regulation of protein localization to nucleus [GO:1900182],
regulation of response to reactive oxygen species [GO:1901031],
negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010],
negative regulation of TORC1 signaling [GO:1904262],
positive regulation of lipophagy [GO:1904504],
cellular response to leucine starvation [GO:1990253],
regulation of cAMP-dependent protein kinase activity [GO:2000479],
mitochondrion organization [GO:0007005],
oxidation-reduction process [GO:0055114],

Molecular Function:
GDP-dissociation inhibitor activity [GO:0005092],
protein binding [GO:0005515],
oxidoreductase activity, acting on peroxide as acceptor [GO:0016684],
sulfiredoxin activity [GO:0032542],
leucine binding [GO:0070728],
oxidoreductase activity [GO:0016491],
peroxiredoxin activity [GO:0051920],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
nucleotide-activated protein kinase complex [GO:0031588],
TORC2 complex [GO:0031932],
GATOR2 complex [GO:0061700],
ATG1/ULK1 kinase complex [GO:1990316],