serpin family F member 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
regulation of blood vessel size by renin-angiotensin [GO:0002034],
platelet degranulation [GO:0002576],
acute-phase response [GO:0006953],
response to organic substance [GO:0010033],
negative regulation of plasminogen activation [GO:0010757],
negative regulation of endopeptidase activity [GO:0010951],
collagen fibril organization [GO:0030199],
positive regulation of collagen biosynthetic process [GO:0032967],
fibrinolysis [GO:0042730],
positive regulation of cell differentiation [GO:0045597],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
blood vessel morphogenesis [GO:0048514],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of stress fiber assembly [GO:0051496],
negative regulation of fibrinolysis [GO:0051918],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of transforming growth factor beta production [GO:0071636],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
negative regulation of peptidase activity [GO:0010466],

Molecular Function:
protease binding [GO:0002020],
endopeptidase inhibitor activity [GO:0004866],
serine-type endopeptidase inhibitor activity [GO:0004867],
protein binding [GO:0005515],
protein homodimerization activity [GO:0042803],
peptidase inhibitor activity [GO:0030414],

Cellular Component:
extracellular region [GO:0005576],
fibrinogen complex [GO:0005577],
extracellular space [GO:0005615],
cell surface [GO:0009986],
platelet alpha granule lumen [GO:0031093],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],