SCN5A

sodium voltage-gated channel alpha subunit 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
regulation of heart rate [GO:0002027],
cardiac ventricle development [GO:0003231],
brainstem development [GO:0003360],
sodium ion transport [GO:0006814],
positive regulation of sodium ion transport [GO:0010765],
response to denervation involved in regulation of muscle adaptation [GO:0014894],
neuronal action potential [GO:0019228],
telencephalon development [GO:0021537],
cerebellum development [GO:0021549],
sodium ion transmembrane transport [GO:0035725],
odontogenesis of dentin-containing tooth [GO:0042475],
positive regulation of action potential [GO:0045760],
positive regulation of epithelial cell proliferation [GO:0050679],
membrane depolarization [GO:0051899],
cardiac muscle contraction [GO:0060048],
regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307],
regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371],
regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372],
regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373],
cardiac conduction [GO:0061337],
cellular response to calcium ion [GO:0071277],
cardiac muscle cell action potential involved in contraction [GO:0086002],
regulation of cardiac muscle cell contraction [GO:0086004],
ventricular cardiac muscle cell action potential [GO:0086005],
membrane depolarization during action potential [GO:0086010],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
atrial cardiac muscle cell action potential [GO:0086014],
SA node cell action potential [GO:0086015],
AV node cell action potential [GO:0086016],
bundle of His cell action potential [GO:0086043],
membrane depolarization during AV node cell action potential [GO:0086045],
membrane depolarization during SA node cell action potential [GO:0086046],
membrane depolarization during Purkinje myocyte cell action potential [GO:0086047],
membrane depolarization during bundle of His cell action potential [GO:0086048],
AV node cell to bundle of His cell communication [GO:0086067],
regulation of heart rate by cardiac conduction [GO:0086091],
membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912],
regulation of sodium ion transmembrane transport [GO:1902305],
ion transport [GO:0006811],
positive regulation of heart rate [GO:0010460],
response to organic cyclic compound [GO:0014070],
regulation of ion transmembrane transport [GO:0034765],
calcium ion homeostasis [GO:0055074],
transmembrane transport [GO:0055085],

Molecular Function:
voltage-gated ion channel activity [GO:0005244],
voltage-gated sodium channel activity [GO:0005248],
cation channel activity [GO:0005261],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
fibroblast growth factor binding [GO:0017134],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
ankyrin binding [GO:0030506],
ubiquitin protein ligase binding [GO:0031625],
ion channel binding [GO:0044325],
nitric-oxide synthase binding [GO:0050998],
voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006],
voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060],
voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061],
voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062],
voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063],
scaffold protein binding [GO:0097110],
ion channel activity [GO:0005216],
sodium channel activity [GO:0005272],

Cellular Component:
voltage-gated sodium channel complex [GO:0001518],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
caveola [GO:0005901],
cell surface [GO:0009986],
intercalated disc [GO:0014704],
integral component of membrane [GO:0016021],
lateral plasma membrane [GO:0016328],
Z disc [GO:0030018],
T-tubule [GO:0030315],
sarcolemma [GO:0042383],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
membrane [GO:0016020],
sodium channel complex [GO:0034706],