AP2 associated kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26583757 HEK 293T, IMR-90, MRC-5 Kidney, Lung Human NO

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
endocytosis [GO:0006897],
regulation of protein localization [GO:0032880],
positive regulation of Notch signaling pathway [GO:0045747],
protein autophosphorylation [GO:0046777],
protein stabilization [GO:0050821],
membrane organization [GO:0061024],
regulation of clathrin-dependent endocytosis [GO:2000369],
phosphorylation [GO:0016310],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
Notch binding [GO:0005112],
protein binding [GO:0005515],
ATP binding [GO:0005524],
AP-2 adaptor complex binding [GO:0035612],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
clathrin-coated pit [GO:0005905],
extrinsic component of plasma membrane [GO:0019897],
clathrin-coated vesicle [GO:0030136],
cell leading edge [GO:0031252],
terminal bouton [GO:0043195],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],
clathrin complex [GO:0071439],
presynapse [GO:0098793],