A2M
alpha-2-macroglobulin
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 21541797 | 2BS | Human | NO | |
| 29548335 | Saos-2, Li-Fraumeni | Human | YES | |
| 30977188 | MSC | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
negative regulation of complement activation, lectin pathway [GO:0001869],
platelet degranulation [GO:0002576],
blood coagulation, intrinsic pathway [GO:0007597],
negative regulation of endopeptidase activity [GO:0010951],
extracellular matrix disassembly [GO:0022617],
stem cell differentiation [GO:0048863],
regulation of small GTPase mediated signal transduction [GO:0051056],
female pregnancy [GO:0007565],
negative regulation of peptidase activity [GO:0010466],
Molecular Function:
protease binding [GO:0002020],
endopeptidase inhibitor activity [GO:0004866],
serine-type endopeptidase inhibitor activity [GO:0004867],
receptor binding [GO:0005102],
protein binding [GO:0005515],
growth factor binding [GO:0019838],
enzyme binding [GO:0019899],
interleukin-8 binding [GO:0019959],
interleukin-1 binding [GO:0019966],
tumor necrosis factor binding [GO:0043120],
calcium-dependent protein binding [GO:0048306],
peptidase inhibitor activity [GO:0030414],
identical protein binding [GO:0042802],
brain-derived neurotrophic factor binding [GO:0048403],
nerve growth factor binding [GO:0048406],
Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytosol [GO:0005829],
platelet alpha granule lumen [GO:0031093],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],