BCL2 apoptosis regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
12387829 Primary fibroblasts derived from rat embryo Rat NO
16545683 Primary cells derived from lung Mouse NO
17882791 MEF, E1a Mouse NO
24050266 U2OS Human NO
27462784 T47-D, MCF7, MDA-MB-231 Human NO
29548335 Saos-2, Li-Fraumeni Human YES
31186408 OV-90,OV-1369,OV-4453,OV-1946 Human YES
31908576 Primary muscle cells derived from artery Rat NO
32029712 Primary synovial fibroblast Human YES
32109515 Brain Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23984931 HMCs Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31593742 Primary cells derived form pituary gland Mouse NO
31799499 IMR-90 Liver Human, mouse NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
ossification [GO:0001503],
ovarian follicle development [GO:0001541],
metanephros development [GO:0001656],
branching involved in ureteric bud morphogenesis [GO:0001658],
behavioral fear response [GO:0001662],
B cell homeostasis [GO:0001782],
release of cytochrome c from mitochondria [GO:0001836],
regulation of cell-matrix adhesion [GO:0001952],
lymphoid progenitor cell differentiation [GO:0002320],
B cell lineage commitment [GO:0002326],
response to ischemia [GO:0002931],
renal system process [GO:0003014],
protein dephosphorylation [GO:0006470],
melanin metabolic process [GO:0006582],
regulation of nitrogen utilization [GO:0006808],
apoptotic process [GO:0006915],
humoral immune response [GO:0006959],
cellular response to DNA damage stimulus [GO:0006974],
actin filament organization [GO:0007015],
axonogenesis [GO:0007409],
female pregnancy [GO:0007565],
cell aging [GO:0007569],
positive regulation of cell proliferation [GO:0008284],
male gonad development [GO:0008584],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
response to radiation [GO:0009314],
response to toxic substance [GO:0009636],
post-embryonic development [GO:0009791],
response to iron ion [GO:0010039],
response to UV-B [GO:0010224],
response to gamma radiation [GO:0010332],
regulation of gene expression [GO:0010468],
negative regulation of autophagy [GO:0010507],
negative regulation of calcium ion transport into cytosol [GO:0010523],
regulation of glycoprotein biosynthetic process [GO:0010559],
mesenchymal cell development [GO:0014031],
positive regulation of neuron maturation [GO:0014042],
positive regulation of smooth muscle cell migration [GO:0014911],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
cytokine-mediated signaling pathway [GO:0019221],
cochlear nucleus development [GO:0021747],
gland morphogenesis [GO:0022612],
regulation of transmembrane transporter activity [GO:0022898],
negative regulation of ossification [GO:0030279],
positive regulation of cell growth [GO:0030307],
negative regulation of cell growth [GO:0030308],
melanocyte differentiation [GO:0030318],
negative regulation of cell migration [GO:0030336],
positive regulation of B cell proliferation [GO:0030890],
hair follicle morphogenesis [GO:0031069],
axon regeneration [GO:0031103],
regulation of protein stability [GO:0031647],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
glomerulus development [GO:0032835],
negative regulation of cellular pH reduction [GO:0032848],
negative regulation of myeloid cell apoptotic process [GO:0033033],
T cell differentiation in thymus [GO:0033077],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of osteoblast proliferation [GO:0033689],
response to cytokine [GO:0034097],
response to nicotine [GO:0035094],
organ growth [GO:0035265],
positive regulation of multicellular organism growth [GO:0040018],
B cell proliferation [GO:0042100],
cellular response to glucose starvation [GO:0042149],
response to drug [GO:0042493],
response to hydrogen peroxide [GO:0042542],
T cell homeostasis [GO:0043029],
negative regulation of apoptotic process [GO:0043066],
positive regulation of catalytic activity [GO:0043085],
CD8-positive, alpha-beta T cell lineage commitment [GO:0043375],
negative regulation of neuron apoptotic process [GO:0043524],
ear development [GO:0043583],
regulation of viral genome replication [GO:0045069],
positive regulation of melanocyte differentiation [GO:0045636],
negative regulation of retinal cell programmed cell death [GO:0046671],
regulation of mitochondrial membrane permeability [GO:0046902],
focal adhesion assembly [GO:0048041],
spleen development [GO:0048536],
thymus development [GO:0048538],
digestive tract morphogenesis [GO:0048546],
oocyte development [GO:0048599],
positive regulation of skeletal muscle fiber development [GO:0048743],
pigment granule organization [GO:0048753],
homeostasis of number of cells within a tissue [GO:0048873],
B cell receptor signaling pathway [GO:0050853],
response to glucocorticoid [GO:0051384],
neuron apoptotic process [GO:0051402],
defense response to virus [GO:0051607],
regulation of mitochondrial membrane potential [GO:0051881],
negative regulation of mitochondrial depolarization [GO:0051902],
regulation of calcium ion transport [GO:0051924],
transmembrane transport [GO:0055085],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
cellular response to hypoxia [GO:0071456],
reactive oxygen species metabolic process [GO:0072593],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
cell-cell adhesion [GO:0098609],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166],
negative regulation of G1/S transition of mitotic cell cycle [GO:2000134],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of anoikis [GO:2000811],
negative regulation of apoptotic signaling pathway [GO:2001234],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
cell morphogenesis [GO:0000902],
response to acid chemical [GO:0001101],
ureteric bud development [GO:0001657],
leukocyte homeostasis [GO:0001776],
kidney development [GO:0001822],
lymphocyte homeostasis [GO:0002260],
T cell lineage commitment [GO:0002360],
immune system development [GO:0002520],
cellular calcium ion homeostasis [GO:0006874],
response to oxidative stress [GO:0006979],
cell proliferation [GO:0008283],
negative regulation of cell proliferation [GO:0008285],
apoptotic mitochondrial changes [GO:0008637],
animal organ morphogenesis [GO:0009887],
regulation of autophagy [GO:0010506],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
hemopoiesis [GO:0030097],
B cell differentiation [GO:0030183],
T cell differentiation [GO:0030217],
regulation of protein localization [GO:0032880],
regulation of growth [GO:0040008],
regulation of apoptotic process [GO:0042981],
regulation of programmed cell death [GO:0043067],
pigmentation [GO:0043473],
response to ethanol [GO:0045471],
negative regulation of mitotic cell cycle [GO:0045930],
developmental pigmentation [GO:0048066],
regulation of developmental pigmentation [GO:0048070],
positive regulation of developmental pigmentation [GO:0048087],
response to steroid hormone [GO:0048545],
developmental growth [GO:0048589],
regulation of catalytic activity [GO:0050790],
regulation of cell cycle [GO:0051726],
cellular response to organic substance [GO:0071310],

Molecular Function:
protease binding [GO:0002020],
protein binding [GO:0005515],
channel activity [GO:0015267],
channel inhibitor activity [GO:0016248],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
BH3 domain binding [GO:0051434],
protein phosphatase 2A binding [GO:0051721],
repressing transcription factor binding [GO:0070491],
transcription factor binding [GO:0008134],
protein phosphatase binding [GO:0019903],
macromolecular complex binding [GO:0044877],
BH domain binding [GO:0051400],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
membrane [GO:0016020],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
myelin sheath [GO:0043209],
pore complex [GO:0046930],
intracellular [GO:0005622],
integral component of membrane [GO:0016021],
mitochondrial crista [GO:0030061],
mitochondrial membrane [GO:0031966],
perinuclear region of cytoplasm [GO:0048471],