RYR1

ryanodine receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
outflow tract morphogenesis [GO:0003151],
calcium ion transport [GO:0006816],
muscle contraction [GO:0006936],
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808],
response to caffeine [GO:0031000],
ion transmembrane transport [GO:0034220],
skin development [GO:0043588],
ossification involved in bone maturation [GO:0043931],
skeletal muscle fiber development [GO:0048741],
release of sequestered calcium ion into cytosol [GO:0051209],
protein homotetramerization [GO:0051289],
regulation of cytosolic calcium ion concentration [GO:0051480],
cellular response to calcium ion [GO:0071277],
cellular response to caffeine [GO:0071313],
regulation of cardiac conduction [GO:1903779],
ion transport [GO:0006811],
cellular calcium ion homeostasis [GO:0006874],
regulation of muscle contraction [GO:0006937],
multicellular organism development [GO:0007275],
transmembrane transport [GO:0055085],
sarcoplasmic reticulum calcium ion transport [GO:0070296],
calcium ion transmembrane transport [GO:0070588],
cellular response to ATP [GO:0071318],

Molecular Function:
protease binding [GO:0002020],
ryanodine-sensitive calcium-release channel activity [GO:0005219],
voltage-gated calcium channel activity [GO:0005245],
calcium channel activity [GO:0005262],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium-release channel activity [GO:0015278],
calcium-induced calcium release activity [GO:0048763],
nucleotide binding [GO:0000166],
ion channel activity [GO:0005216],
enzyme binding [GO:0019899],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasm [GO:0005737],
smooth endoplasmic reticulum [GO:0005790],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell cortex [GO:0005938],
junctional sarcoplasmic reticulum membrane [GO:0014701],
terminal cisterna [GO:0014802],
sarcoplasmic reticulum [GO:0016529],
Z disc [GO:0030018],
junctional membrane complex [GO:0030314],
T-tubule [GO:0030315],
cytoplasmic vesicle membrane [GO:0030659],
integral component of organelle membrane [GO:0031301],
I band [GO:0031674],
sarcoplasmic reticulum membrane [GO:0033017],
calcium channel complex [GO:0034704],
sarcolemma [GO:0042383],
extracellular exosome [GO:0070062],
ryanodine receptor complex [GO:1990425],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
macromolecular complex [GO:0032991],