RXRA

retinoid X receptor alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29748541 MCF7, hBM-MSC Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30216632 MRC5 Human NO
31945125 Primary astrocytes derived from brain Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
in utero embryonic development [GO:0001701],
maternal placenta development [GO:0001893],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription initiation from RNA polymerase II promoter [GO:0006367],
vitamin metabolic process [GO:0006766],
embryo implantation [GO:0007566],
cholesterol metabolic process [GO:0008203],
bile acid and bile salt transport [GO:0015721],
modulation by virus of host morphology or physiology [GO:0019048],
regulation of lipid metabolic process [GO:0019216],
cell differentiation [GO:0030154],
response to retinoic acid [GO:0032526],
peroxisome proliferator activated receptor signaling pathway [GO:0035357],
camera-type eye development [GO:0043010],
steroid hormone mediated signaling pathway [GO:0043401],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of translational initiation by iron [GO:0045994],
retinoic acid receptor signaling pathway [GO:0048384],
anatomical structure development [GO:0048856],
ventricular cardiac muscle tissue morphogenesis [GO:0055010],
ventricular cardiac muscle cell differentiation [GO:0055012],
cardiac muscle cell proliferation [GO:0060038],
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528],
regulation of branching involved in prostate gland morphogenesis [GO:0060687],
placenta development [GO:0001890],
heart morphogenesis [GO:0003007],
regulation of transcription, DNA-templated [GO:0006355],
heart development [GO:0007507],
negative regulation of cell proliferation [GO:0008285],
negative regulation of gene expression [GO:0010629],
regulation of myelination [GO:0031641],
positive regulation of apoptotic process [GO:0043065],
positive regulation of transcription, DNA-templated [GO:0045893],
response to glucocorticoid [GO:0051384],
cardiac muscle cell differentiation [GO:0055007],
mesenchyme development [GO:0060485],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
visceral serous pericardium development [GO:0061032],
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162],
retinoic acid binding [GO:0001972],
DNA binding [GO:0003677],
double-stranded DNA binding [GO:0003690],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
steroid hormone receptor activity [GO:0003707],
transcription coactivator activity [GO:0003713],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
ligand-dependent nuclear receptor binding [GO:0016922],
enzyme binding [GO:0019899],
chromatin DNA binding [GO:0031490],
signaling receptor activity [GO:0038023],
peptide binding [GO:0042277],
identical protein binding [GO:0042802],
vitamin D receptor binding [GO:0042809],
sequence-specific DNA binding [GO:0043565],
retinoic acid-responsive element binding [GO:0044323],
DBD domain binding [GO:0050692],
LBD domain binding [GO:0050693],
vitamin D response element binding [GO:0070644],
transcription factor binding [GO:0008134],
protein domain specific binding [GO:0019904],
retinoic acid receptor binding [GO:0042974],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
macromolecular complex [GO:0032991],
host cell nucleus [GO:0042025],
receptor complex [GO:0043235],
RNA polymerase II transcription factor complex [GO:0090575],
cytoplasm [GO:0005737],
axon [GO:0030424],