rubicon autophagy regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
immune system process [GO:0002376],
endocytosis [GO:0006897],
phagocytosis [GO:0006909],
autophagy [GO:0006914],
negative regulation of autophagy [GO:0010507],
negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553],
negative regulation of endocytosis [GO:0045806],
multivesicular body sorting pathway [GO:0071985],
negative regulation of autophagosome maturation [GO:1901097],

Molecular Function:
protein binding [GO:0005515],
phosphatidylinositol phosphate binding [GO:1901981],

Cellular Component:
nucleoplasm [GO:0005654],
lysosome [GO:0005764],
early endosome [GO:0005769],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
intracellular membrane-bounded organelle [GO:0043231],
endosome [GO:0005768],