RPS6KA6

ribosomal protein S6 kinase A6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19584160 IMR-90, HCT-116 Colon, Kidney Human NO
21239520 TIG-3 Human NO
27986634 MDA-MB-231 Human NO
29548335 Saos-2 Human YES

GO terms:

Biological Process:
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978],
signal transduction [GO:0007165],
central nervous system development [GO:0007417],
negative regulation of embryonic development [GO:0045992],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
negative regulation of mesoderm development [GO:2000381],
phosphorylation [GO:0016310],

Molecular Function:
magnesium ion binding [GO:0000287],
protein kinase activity [GO:0004672],
ribosomal protein S6 kinase activity [GO:0004711],
ATP binding [GO:0005524],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
fibrillar center [GO:0001650],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
mitochondrion [GO:0005739],
cytosol [GO:0005829],