ribosomal protein S6 kinase A2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
signal transduction [GO:0007165],
negative regulation of cell proliferation [GO:0008285],
positive regulation of apoptotic process [GO:0043065],
negative regulation of cell cycle [GO:0045786],
oocyte maturation [GO:0001556],
brain renin-angiotensin system [GO:0002035],
protein phosphorylation [GO:0006468],
heart development [GO:0007507],
positive regulation of gene expression [GO:0010628],
cardiac muscle cell apoptotic process [GO:0010659],
phosphorylation [GO:0016310],
peptidyl-serine phosphorylation [GO:0018105],
negative regulation of meiotic nuclear division [GO:0045835],
heart contraction [GO:0060047],
regulation of protein processing [GO:0070613],
cellular response to carbohydrate stimulus [GO:0071322],

Molecular Function:
magnesium ion binding [GO:0000287],
ribosomal protein S6 kinase activity [GO:0004711],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein binding [GO:0005515],
ATP binding [GO:0005524],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
spindle [GO:0005819],
meiotic spindle [GO:0072687],