ribosomal protein S6 kinase A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31476350 HUVEC, primary endothelial cells derived from heart, primary endothelial cells derived from lung Human, mouse NO

GO terms:

Biological Process:
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
positive regulation of cell growth [GO:0030307],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of translation in response to stress [GO:0043555],
regulation of DNA-templated transcription in response to stress [GO:0043620],
positive regulation of cell differentiation [GO:0045597],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
hepatocyte proliferation [GO:0072574],
positive regulation of hepatic stellate cell activation [GO:2000491],
protein phosphorylation [GO:0006468],
phosphorylation [GO:0016310],
positive regulation of transcription, DNA-templated [GO:0045893],

Molecular Function:
magnesium ion binding [GO:0000287],
protein serine/threonine kinase activity [GO:0004674],
ribosomal protein S6 kinase activity [GO:0004711],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein binding [GO:0005515],
ATP binding [GO:0005524],
cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transcription factor binding [GO:0008134],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
spindle [GO:0005819],