bromodomain adjacent to zinc finger domain 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
chromatin silencing at rDNA [GO:0000183],
RNA polymerase I transcriptional preinitiation complex assembly [GO:0001188],
DNA methylation [GO:0006306],
chromatin remodeling [GO:0006338],
transcription, DNA-templated [GO:0006351],
regulation of transcription, DNA-templated [GO:0006355],
histone deacetylation [GO:0016575],
chromatin organization [GO:0006325],
negative regulation of transcription from RNA polymerase I promoter [GO:0016479],
heterochromatin assembly [GO:0031507],
histone H4-K20 methylation [GO:0034770],
histone H3-K9 methylation [GO:0051567],
histone H4 deacetylation [GO:0070933],

Molecular Function:
RNA polymerase I CORE element sequence-specific DNA binding [GO:0001164],
RNA binding [GO:0003723],
protein binding [GO:0005515],
ligand-dependent nuclear receptor binding [GO:0016922],
histone binding [GO:0042393],
metal ion binding [GO:0046872],
lysine-acetylated histone binding [GO:0070577],
DNA binding [GO:0003677],

Cellular Component:
chromatin silencing complex [GO:0005677],
nucleolus [GO:0005730],
cytosol [GO:0005829],
nuclear speck [GO:0016607],
rDNA heterochromatin [GO:0033553],
host cell nucleus [GO:0042025],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],