ROCK2

Rho associated coiled-coil containing protein kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
positive regulation of protein phosphorylation [GO:0001934],
response to ischemia [GO:0002931],
aortic valve morphogenesis [GO:0003180],
protein phosphorylation [GO:0006468],
smooth muscle contraction [GO:0006939],
G-protein coupled receptor signaling pathway [GO:0007186],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
Rho protein signal transduction [GO:0007266],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of centrosome duplication [GO:0010825],
negative regulation of angiogenesis [GO:0016525],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
regulation of cell adhesion [GO:0030155],
positive regulation of cell migration [GO:0030335],
cortical actin cytoskeleton organization [GO:0030866],
actomyosin structure organization [GO:0031032],
regulation of neurological system process [GO:0031644],
positive regulation of connective tissue growth factor production [GO:0032723],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of myosin-light-chain-phosphatase activity [GO:0035509],
viral RNA genome replication [GO:0039694],
regulation of circadian rhythm [GO:0042752],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
regulation of keratinocyte differentiation [GO:0045616],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
rhythmic process [GO:0048511],
embryonic morphogenesis [GO:0048598],
regulation of protein metabolic process [GO:0051246],
centrosome duplication [GO:0051298],
regulation of stress fiber assembly [GO:0051492],
positive regulation of stress fiber assembly [GO:0051496],
regulation of focal adhesion assembly [GO:0051893],
mRNA destabilization [GO:0061157],
negative regulation of biomineral tissue development [GO:0070168],
cellular response to testosterone stimulus [GO:0071394],
response to transforming growth factor beta [GO:0071559],
protein localization to plasma membrane [GO:0072659],
positive regulation of fibroblast growth factor production [GO:0090271],
regulation of cellular response to hypoxia [GO:1900037],
regulation of cell junction assembly [GO:1901888],
positive regulation of beta-amyloid formation [GO:1902004],
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961],
positive regulation of protein localization to early endosome [GO:1902966],
positive regulation of amyloid precursor protein catabolic process [GO:1902993],
regulation of establishment of endothelial barrier [GO:1903140],
negative regulation of bicellular tight junction assembly [GO:1903347],
cellular response to acetylcholine [GO:1905145],
positive regulation of connective tissue replacement [GO:1905205],
response to angiotensin [GO:1990776],
regulation of establishment of cell polarity [GO:2000114],
regulation of cell motility [GO:2000145],
neural tube closure [GO:0001843],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
phosphorylation [GO:0016310],
actin cytoskeleton organization [GO:0030036],
intracellular signal transduction [GO:0035556],
dendrite morphogenesis [GO:0048813],
postsynaptic actin cytoskeleton organization [GO:0098974],

Molecular Function:
RNA binding [GO:0003723],
protein serine/threonine kinase activity [GO:0004674],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
ATP binding [GO:0005524],
GTP-Rho binding [GO:0017049],
metal ion binding [GO:0046872],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
Rho-dependent protein serine/threonine kinase activity [GO:0072518],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Rho GTPase binding [GO:0017048],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cytoplasmic ribonucleoprotein granule [GO:0036464],
membrane [GO:0016020],
spindle pole centrosome [GO:0031616],
glutamatergic synapse [GO:0098978],