Rho associated coiled-coil containing protein kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31806373 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
aortic valve morphogenesis [GO:0003180],
apical constriction [GO:0003383],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
smooth muscle contraction [GO:0006939],
leukocyte cell-cell adhesion [GO:0007159],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
Rho protein signal transduction [GO:0007266],
regulation of autophagy [GO:0010506],
positive regulation of autophagy [GO:0010508],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of gene expression [GO:0010628],
negative regulation of endopeptidase activity [GO:0010951],
negative regulation of angiogenesis [GO:0016525],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
membrane to membrane docking [GO:0022614],
actin cytoskeleton organization [GO:0030036],
regulation of cell adhesion [GO:0030155],
regulation of cell migration [GO:0030334],
cortical actin cytoskeleton organization [GO:0030866],
actomyosin structure organization [GO:0031032],
neuron projection development [GO:0031175],
bleb assembly [GO:0032060],
negative regulation of protein binding [GO:0032091],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of myosin-light-chain-phosphatase activity [GO:0035509],
neutrophil degranulation [GO:0043312],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of keratinocyte differentiation [GO:0045616],
regulation of neuron differentiation [GO:0045664],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
embryonic morphogenesis [GO:0048598],
leukocyte migration [GO:0050900],
leukocyte tethering or rolling [GO:0050901],
negative regulation of membrane protein ectodomain proteolysis [GO:0051045],
myoblast migration [GO:0051451],
regulation of stress fiber assembly [GO:0051492],
regulation of focal adhesion assembly [GO:0051893],
positive regulation of focal adhesion assembly [GO:0051894],
mRNA destabilization [GO:0061157],
negative regulation of biomineral tissue development [GO:0070168],
regulation of microtubule cytoskeleton organization [GO:0070507],
response to transforming growth factor beta [GO:0071559],
protein localization to plasma membrane [GO:0072659],
positive regulation of beta-amyloid clearance [GO:1900223],
regulation of synaptic vesicle endocytosis [GO:1900242],
regulation of cell junction assembly [GO:1901888],
regulation of beta-amyloid formation [GO:1902003],
negative regulation of beta-amyloid formation [GO:1902430],
negative regulation of amyloid precursor protein catabolic process [GO:1902992],
regulation of establishment of endothelial barrier [GO:1903140],
negative regulation of bicellular tight junction assembly [GO:1903347],
positive regulation of connective tissue replacement [GO:1905205],
response to angiotensin [GO:1990776],
regulation of establishment of cell polarity [GO:2000114],
regulation of cell motility [GO:2000145],
cytoskeleton organization [GO:0007010],
phosphorylation [GO:0016310],
regulation of actin filament-based process [GO:0032970],
intracellular signal transduction [GO:0035556],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
GTP-Rho binding [GO:0017049],
aspartic-type endopeptidase inhibitor activity [GO:0019828],
metal ion binding [GO:0046872],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
Rho-dependent protein serine/threonine kinase activity [GO:0072518],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Rho GTPase binding [GO:0017048],

Cellular Component:
Golgi membrane [GO:0000139],
ruffle [GO:0001726],
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
centriole [GO:0005814],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cytoplasmic stress granule [GO:0010494],
lamellipodium [GO:0030027],
bleb [GO:0032059],
secretory granule lumen [GO:0034774],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
cell projection [GO:0042995],